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The Effective Calcium/Calmodulin Concentration Determines the Sensitivity of CaMKII to the Frequency of Calcium Oscillations

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Part of the Lecture Notes in Computer Science book series (LNTCS,volume 7223)

Abstract

Calcium/calmodulin-dependent protein kinase II (CaMKII) is involved in the induction of many forms of synaptic plasticity in the brain. Experimental and computational studies have shown that CaMKII is sensitive to the frequency of oscillatory Ca2 +  signals. Here we demonstrate that in a simple, commonly used kinetic model of CaMKII phosphorylation, the overall phosphorylation rate under sustained application of Ca4 − CaM pulses ultimately depends on the average (‘effective’) concentration of Ca4 − CaM in the system, rather than on the pulse frequency itself. As a corollary, equal phosphorylation levels are achieved in response to pulsed and constant applications of equal effective concentrations of Ca4 − CaM.

Keywords

  • CaMKII
  • calmodulin
  • Ca2 +  oscillations

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© 2012 Springer-Verlag Berlin Heidelberg

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Pinto, T.M., Schilstra, M.J., Steuber, V. (2012). The Effective Calcium/Calmodulin Concentration Determines the Sensitivity of CaMKII to the Frequency of Calcium Oscillations. In: Lones, M.A., Smith, S.L., Teichmann, S., Naef, F., Walker, J.A., Trefzer, M.A. (eds) Information Processign in Cells and Tissues. IPCAT 2012. Lecture Notes in Computer Science, vol 7223. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28792-3_17

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  • DOI: https://doi.org/10.1007/978-3-642-28792-3_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-28791-6

  • Online ISBN: 978-3-642-28792-3

  • eBook Packages: Computer ScienceComputer Science (R0)