Advance in Corneal Imaging

  • Antoine Labbé
  • Alexandre Denoyer
  • Christophe Baudouin
Chapter

Abstract

Many clinical situations require a precise assessment of corneal structures. However, the resolution of ophthalmic instruments such as the slit-lamp is limited and, for ophthalmologists, it has always been a challenge to evaluate qualitatively and quantitatively the microscopic structures of the cornea. Recently, new imaging techniques have thus been developed to overcome these limitations of light biomicroscopy.

Keywords

Ocular Coherence Tomography Amniotic Membrane Refractive Surgery Corneal Graft Corneal Dystrophy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Conflict of Interest

The authors have no proprietary or commercial interest in any product or concept discussed in this article.

References

  1. 1.
    Zhivov A, Stachs O, Kraak R et al (2006) In vivo confocal microscopy of the ocular surface. Ocul Surf 4(2):81–93PubMedCrossRefGoogle Scholar
  2. 2.
    Labbe A, Khammari C, Dupas B et al (2009) Contribution of in vivo confocal microscopy to the diagnosis and management of infectious keratitis. Ocul Surf 7(1):41–52PubMedCrossRefGoogle Scholar
  3. 3.
    Brasnu E, Bourcier T, Dupas B et al (2007) In vivo confocal microscopy in fungal keratitis. Br J Ophthalmol 91(5):588–591PubMedCrossRefGoogle Scholar
  4. 4.
    Kaufman SC, Musch DC, Belin MW et al (2004) Confocal microscopy: a report by the American Academy of Ophthalmology. Ophthalmology 111(2):396–406PubMedCrossRefGoogle Scholar
  5. 5.
    Niederer RL, McGhee CN (2010) Clinical in vivo confocal microscopy of the human cornea in health and disease. Prog Retin Eye Res 29(1):30–58PubMedCrossRefGoogle Scholar
  6. 6.
    Patel DV, Grupcheva CN, McGhee CN (2005) Imaging the microstructural abnormalities of meesmann corneal dystrophy by in vivo confocal microscopy. Cornea 24(6):669–673PubMedCrossRefGoogle Scholar
  7. 7.
    Labbe A, Nicola RD, Dupas B et al (2006) Epithelial basement membrane dystrophy: evaluation with the HRT II Rostock Cornea Module. Ophthalmology 113(8):1301–1308PubMedCrossRefGoogle Scholar
  8. 8.
    Kobayashi A, Sugiyama K (2007) In vivo laser confocal microscopy findings for Bowman’s layer dystrophies (Thiel-Behnke and Reis-Bucklers corneal dystrophies). Ophthalmology 114(1):69–75PubMedCrossRefGoogle Scholar
  9. 9.
    Kaufman SC, Kaufman HE (2006) How has confocal microscopy helped us in refractive surgery? Curr Opin Ophthalmol 17(4):380–388PubMedCrossRefGoogle Scholar
  10. 10.
    Jalbert I, Stapleton F, Papas E et al (2003) In vivo confocal microscopy of the human cornea. Br J Ophthalmol 87(2):225–236PubMedCrossRefGoogle Scholar
  11. 11.
    Sonigo B, Iordanidou V, Chong-Sit D et al (2006) In vivo corneal confocal microscopy comparison of intralase femtosecond laser and mechanical microkeratome for laser in situ keratomileusis. Invest Ophthalmol Vis Sci 47(7):2803–2811PubMedCrossRefGoogle Scholar
  12. 12.
    Erie JC, Nau CB, McLaren JW et al (2004) Long-term keratocyte deficits in the corneal stroma after LASIK. Ophthalmology 111(7):1356–1361PubMedCrossRefGoogle Scholar
  13. 13.
    Calvillo MP, McLaren JW, Hodge DO, Bourne WM (2004) Corneal reinnervation after LASIK: prospective 3-year longitudinal study. Invest Ophthalmol Vis Sci 45(11):3991–3996PubMedCrossRefGoogle Scholar
  14. 14.
    Niederer RL, Perumal D, Sherwin T, McGhee CN (2007) Corneal innervation and cellular changes after corneal transplantation: an in vivo confocal microscopy study. Invest Ophthalmol Vis Sci 48(2):621–626PubMedCrossRefGoogle Scholar
  15. 15.
    Niederer RL, Sherwin T, McGhee CN (2007) In vivo confocal microscopy of subepithelial infiltrates in human corneal transplant rejection. Cornea 26(4):501–504PubMedCrossRefGoogle Scholar
  16. 16.
    Mazzotta C, Balestrazzi A, Traversi C et al (2007) Treatment of progressive keratoconus by riboflavin-UVA-induced cross-linking of corneal collagen: ultrastructural analysis by Heidelberg Retinal Tomograph II in vivo confocal microscopy in humans. Cornea 26(4):390–397PubMedCrossRefGoogle Scholar
  17. 17.
    Labbe A, Dupas B, Hamard P, Baudouin C (2005) In vivo confocal microscopy study of blebs after filtering surgery. Ophthalmology 112(11):1979PubMedCrossRefGoogle Scholar
  18. 18.
    Prakash G, Agarwal A, Jacob S (2009) Comparison of Fourier-domain and time-domain optical coherence tomography for assessment of corneal thickness and intersession repeatability. Am J Ophthalmol 148(2):282–90.e2PubMedCrossRefGoogle Scholar
  19. 19.
    Simpson T, Fonn D (2008) Optical coherence tomography of the anterior segment. Ocul Surf 6(3):117–127PubMedCrossRefGoogle Scholar
  20. 20.
    Knuttel A, Bonev S, Knaak W (2004) New method for evaluation of in vivo scattering and refractive index properties obtained with optical coherence tomography. J Biomed Opt 9(2):265–273PubMedCrossRefGoogle Scholar
  21. 21.
    Li Y, Netto MV, Shekhar R et al (2007) A longitudinal study of LASIK flap and stromal thickness with high-speed optical coherence tomography. Ophthalmology 114(6):1124–1132PubMedCrossRefGoogle Scholar
  22. 22.
    Stahl JE, Durrie DS, Schwendeman FJ, Boghossian AJ (2007) Anterior segment OCT analysis of thin IntraLase femtosecond flaps. J Refract Surg 23(6):555–558PubMedGoogle Scholar
  23. 23.
    Ustundag C, Bahcecioglu H, Ozdamar A et al (2000) Optical coherence tomography for evaluation of anatomical changes in the cornea after laser in situ keratomileusis. J Cataract Refract Surg 26(10):1458–1462PubMedCrossRefGoogle Scholar
  24. 24.
    Baikoff G (2006) Anterior segment OCT and phakic intraocular lenses: a perspective. J Cataract Refract Surg 32(11):1827–1835PubMedCrossRefGoogle Scholar
  25. 25.
    Shih CY, Ritterband DC, Palmiero PM (2009) The use of postoperative slit-lamp optical coherence tomography to predict primary failure in descemet stripping automated endothelial keratoplasty. Am J Ophthalmol 147(5):796–800, e1PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Antoine Labbé
    • 1
  • Alexandre Denoyer
    • 1
  • Christophe Baudouin
    • 1
  1. 1.Department of Ophthalmology IIIQuinze-Vingts National Ophthalmology HospitalParisFrance

Personalised recommendations