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New Developments in Antibacterial Chemotherapy for Bacterial Keratitis

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Corneal Disease

Abstract

The treatment of bacterial keratitis depends on identifying the causative agent and selecting an appropriate antimicrobial.

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References

  1. Bharathi MJ et al (2007) Microbial keratitis in South India: influence of risk factors, climate, and geographical variation. Ophthalmic Epidemiol 14(2):61–69

    Article  PubMed  Google Scholar 

  2. Waring GO, Laibson PR (1977) A systematic method of drawing corneal pathologic conditions. Arch Ophthalmol 95(9):1540–1542

    Article  PubMed  CAS  Google Scholar 

  3. Liesegang TJ (1997) Contact lens-related microbial keratitis: part I: epidemiology. Cornea 16(2):125–131

    PubMed  CAS  Google Scholar 

  4. Sharma S et al (2003) Trends in contact lens-associated microbial keratitis in Southern India. Ophthalmology 110(1):138–143

    Article  PubMed  Google Scholar 

  5. Bourcier T et al (2003) Bacterial keratitis: predisposing factors, clinical and microbiological review of 300 cases. Br J Ophthalmol 87(7):834–838

    Article  PubMed  CAS  Google Scholar 

  6. Schaefer F et al (2001) Bacterial keratitis: a prospective clinical and microbiological study. Br J Ophthalmol 85(7):842–847

    Article  PubMed  CAS  Google Scholar 

  7. Lam DS et al (2002) Incidence and risk factors for microbial keratitis in Hong Kong: comparison with Europe and North America. Eye (Lond) 16(5):608–618

    Article  CAS  Google Scholar 

  8. Fahmy JA, Moller S, Bentzon MW (1974) Bacterial flora of the normal conjunctiva. I. Topographical distribution. Acta Ophthalmol (Copenh) 52(6):786–800

    Article  CAS  Google Scholar 

  9. Fukuda M et al (2002) Methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative Staphylococcus ocular surface infection efficacy of chloramphenicol eye drops. Cornea 21(7 Suppl):S86–S89

    Article  PubMed  Google Scholar 

  10. Kaye S et al (2010) Bacterial susceptibility to topical antimicrobials and clinical outcome in bacterial keratitis. Invest Ophthalmol Vis Sci 51(1):362–368

    Article  PubMed  Google Scholar 

  11. Sueke H et al (2010) Minimum inhibitory concentrations of standard and novel antimicrobials for isolates from bacterial keratitis. Invest Ophthalmol Vis Sci 51(5):2519–2524

    Article  PubMed  Google Scholar 

  12. Tuft SJ, Matheson M (2000) In vitro antibiotic resistance in bacterial keratitis in London. Br J Ophthalmol 84(7):687–691

    Article  PubMed  CAS  Google Scholar 

  13. Bharathi MJ et al (2003) Epidemiology of bacterial keratitis in a referral centre in south India. Indian J Med Microbiol 21(4):239–245

    PubMed  CAS  Google Scholar 

  14. McDonnell PJ (1996) Empirical or culture-guided therapy for microbial keratitis? A plea for data. Arch Ophthalmol 114(1):84–87

    Article  PubMed  CAS  Google Scholar 

  15. Kaye SB et al (2003) Simplifying collection of corneal specimens in cases of suspected bacterial keratitis. J Clin Microbiol 41(7):3192–3197

    Article  PubMed  Google Scholar 

  16. Itahashi M et al (2010) Detection and quantification of pathogenic bacteria and fungi using real-time polymerase chain reaction by cycling probe in patients with corneal ulcer. Arch Ophthalmol 128(5):535–540

    Article  PubMed  CAS  Google Scholar 

  17. Subrayan V et al (2010) Assessment of polymerase chain reaction in the detection of Pseudomonas aeruginosa in contact lens-induced severe infectious keratitis. Eye Contact Lens 36(4):201–203

    Article  PubMed  Google Scholar 

  18. Kaye SB et al (2009) Concentration and bioavailability of ciprofloxacin and teicoplanin in the cornea. Invest Ophthalmol Vis Sci 50(7):3176–3184

    Article  PubMed  Google Scholar 

  19. Urtti A (2006) Challenges and obstacles of ocular pharmacokinetics and drug delivery. Adv Drug Deliv Rev 58(11):1131–1135

    Article  PubMed  CAS  Google Scholar 

  20. Baum J, Barza M (2000) The evolution of antibiotic therapy for bacterial conjunctivitis and keratitis: 1970–2000. Cornea 19(5):659–672

    Article  PubMed  CAS  Google Scholar 

  21. Goldstein MH, Kowalski RP, Gordon YJ (1999) Emerging fluoroquinolone resistance in bacterial keratitis: a 5-year review. Ophthalmology 106(7):1313–1318

    Article  PubMed  CAS  Google Scholar 

  22. Garg P, Sharma S, Rao GN (1999) Ciprofloxacin-resistant Pseudomonas keratitis. Ophthalmology 106(7):1319–1323

    Article  PubMed  CAS  Google Scholar 

  23. Moshirfar M et al (2006) Fourth-generation fluoroquinolone-resistant bacterial keratitis after refractive surgery. J Cataract Refract Surg 32(3):515–518

    Article  PubMed  Google Scholar 

  24. Jhanji V et al (2007) Fourth-generation fluoroquinolone-resistant bacterial keratitis. J Cataract Refract Surg 33(8):1488–1489

    Article  PubMed  Google Scholar 

  25. Park SH et al (2009) The resistance patterns of normal ocular bacterial flora to 4 fluoroquinolone antibiotics. Cornea 28(1):68–72

    Article  PubMed  Google Scholar 

  26. Kim DH, Stark WJ, O’Brien TP (2005) Ocular penetration of moxifloxacin 0.5% and gatifloxacin 0.3% ophthalmic solutions into the aqueous humor following topical administration prior to routine cataract surgery. Curr Med Res Opin 21(1):93–94

    Article  PubMed  CAS  Google Scholar 

  27. Sugioka K et al (2009) Intraocular penetration of sequentially instilled topical moxifloxacin, gatifloxacin, and levofloxacin. Clin Ophthalmol 3:553–557

    Article  PubMed  CAS  Google Scholar 

  28. Yagci R et al (2007) Penetration of second-, third-, and fourth-generation topical fluoroquinolone into aqueous and vitreous humour in a rabbit endophthalmitis model. Eye (Lond) 21(7):990–994

    Article  CAS  Google Scholar 

  29. Alfonso EC et al (1990) In vitro toxicity of gentamicin to corneal epithelial cells. Cornea 9(1):55–61

    Article  PubMed  CAS  Google Scholar 

  30. Baum J (1982) Treatment of bacterial ulcers of the cornea in the rabbit: a comparison of administration by eye drops and subconjunctival injections. Trans Am Ophthalmol Soc 80:369–390

    PubMed  CAS  Google Scholar 

  31. Jenkins CD et al (1996) Comparative intraocular penetration of topical and injected cefuroxime. Br J Ophthalmol 80(8):685–688

    Article  PubMed  CAS  Google Scholar 

  32. Karpecki P (2009) Besifloxacin ophthalmic suspension 0.6% in patients with bacterial conjunctivitis: a multicenter, prospective, randomized, double-masked, vehicle-controlled, 5-day efficacy and safety study. Clin Ther 31(3):514–526

    Article  PubMed  CAS  Google Scholar 

  33. Proksch JW et al (2009) Ocular pharmacokinetics of besifloxacin following topical administration to rabbits, monkeys, and humans. J Ocul Pharmacol Ther 25(4):335–344

    Article  PubMed  CAS  Google Scholar 

  34. Sanders ME et al (2011) Comparison of besifloxacin, gatifloxacin, and moxifloxacin against strains of Pseudomonas aeruginosa with different quinolone susceptibility patterns in a rabbit model of keratitis. Cornea 30(1):83–90

    Article  PubMed  Google Scholar 

  35. Sanders ME et al (2009) Efficacy of besifloxacin in a rabbit model of methicillin-resistant Staphylococcus aureus keratitis. Cornea 28(9):1055–1060

    Article  PubMed  Google Scholar 

  36. Pankey GA (2005) Tigecycline. J Antimicrob Chemother 56(3):470–480

    Article  PubMed  CAS  Google Scholar 

  37. Moellering RC (2003) Linezolid: the first oxazolidinone antimicrobial. Ann Intern Med 138(2):135–142

    PubMed  CAS  Google Scholar 

  38. Ekdawi NS (2005) Topical linezolid in Streptococcus pneumoniae corneal ulcer model in rabbits. Invest Ophthalmol Vis Sci 46(5):4910

    Google Scholar 

  39. Saleh M (2010) Ocular penetration of topically applied linezolid in a rabbit model. J Cataract Refract Surg 36(3):488–492

    Article  PubMed  Google Scholar 

  40. Baldwin CM, Lyseng-Williamson KA, Keam SJ (2008) Meropenem: a review of its use in the treatment of serious bacterial infections. Drugs 68(6):803–838

    Article  PubMed  CAS  Google Scholar 

  41. Manav C (2004) Comparison of intravitreal ceftazidime and meropenem in treatment of experimental pseudomonal posttraumatic endophthalmitis in a rabbit model. J Appl Res 4(2):337–345

    Google Scholar 

  42. Schauersberger J et al (1999) Penetration and decay of meropenem into the human aqueous humor and vitreous. J Ocul Pharmacol Ther 15(5):439–445

    Article  PubMed  CAS  Google Scholar 

  43. Moellering RC Jr, Wennersten C, Weinberg AN (1971) Synergy of penicillin and gentamicin against Enterococci. J Infect Dis 124(Suppl):S207–S209

    Article  PubMed  CAS  Google Scholar 

  44. Winstanley TG, Hastings JG (1990) Synergy between penicillin and gentamicin against enterococci. J Antimicrob Chemother 25(4):551–560

    Article  PubMed  CAS  Google Scholar 

  45. Friedland IR, Klugman KP (1992) Failure of chloramphenicol therapy in penicillin-resistant pneumococcal meningitis. Lancet 339(8790):405–408

    Article  PubMed  CAS  Google Scholar 

  46. Sueke H et al (2010) An in vitro investigation of synergy or antagonism between antimicrobial combinations against isolates from bacterial keratitis. Invest Ophthalmol Vis Sci 51(8):4151–4155

    Article  PubMed  Google Scholar 

  47. Kearns VR, Williams RL (2009) Drug delivery systems for the eye. Expert Rev Med Devices 6(3):277–290

    Article  PubMed  CAS  Google Scholar 

  48. Behar-Cohen F (2002) Drug delivery systems to target the anterior segment of the eye: fundamental bases and clinical applications. J Fr Ophtalmol 25(5):537–544

    PubMed  CAS  Google Scholar 

  49. Luchs JI, Nelinson DS, Macy JI (2010) Efficacy of hydroxypropyl cellulose ophthalmic inserts (LACRISERT) in subsets of patients with dry eye syndrome: findings from a patient registry. Cornea 29(12):1417–1427

    Article  PubMed  Google Scholar 

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Sueke, H., Shankar, J., Neal, T.J., Horsburgh, M., Gilbert, R., Kaye, S.B. (2013). New Developments in Antibacterial Chemotherapy for Bacterial Keratitis. In: Reinhard, T., Larkin, F. (eds) Corneal Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28747-3_2

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  • DOI: https://doi.org/10.1007/978-3-642-28747-3_2

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