mRNA Turnover in Trypanosomes
Most kinetoplastid mRNAs are synthesised by RNA polymerase II, then trans spliced, polyadenylated, and exported from the nucleus. The polycistronic nature of kinetoplastid transcription, however, means that—with a few exceptions—the amount of mRNA is determined by post-transcriptionally. Once in the cytoplasm, the amount of mRNA is determined by the rate of mRNA degradation and the amount of protein by the rates of translation initiation, elongation, and protein turnover. In many cases, regulation of mRNA turnover has been found to play a dominant role. This review discusses the mechanisms of mRNA degradation in kinetoplastids, and how that degradation is controlled.
KeywordsmRNA Degradation Stress Granule Premature Termination Codon Procyclic Form CCCH Zinc Finger
Work in my laboratory is supported by the Land of Baden-Württemberg and the Deutsche Forschungsgemeinschaft.
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