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Potential Mechanisms of Metabolic SuppressionDownstream of Central A1AR Activation During Onset of Torpor

  • Tulasi R. Jinka
  • Zachary A. Barrickman
  • Lori K. Bogren
  • Trixie N. Lee
  • Jasmine M. Olson
  • Melanie M. Richter
  • Brady M. Salli
  • Timothy J. Stevenson
  • Øivind Tøien
  • C. Loren Buck
  • Kelly L. Drew
Chapter

Abstract

Hibernating animals demonstrate a nadir in metabolic demand and body temperature (T b) during torpor that is fundamental to adaptation to seasonal periods of reduced resource availability. A recent study shows how the brain regulates metabolic suppression during onset of torpor suggesting that central A1 adenosine receptor signaling is both necessary and sufficient to trigger decreases in metabolic rate and T b. This leads to an interesting question of how central signals are transduced to the periphery to elicit global suppression of metabolism and this chapter discusses relevant hypotheses.

Keywords

Basal Metabolic Rate Ground Squirrel Ghrelin Level Metabolic Suppression Torpor Bout 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations

A1AR

A1 adenosine receptor

ANS

Autonomic nervous system

BMR

Basal metabolic rate

CHA

N6-Cyclohexyladenosine

CNS

Central nervous system

HIT

Hibernation induction trigger

H2S

Hydrogen sulfide

kD

Kilodalton

KO

Knockout

MR

Metabolic rate

PNS

Parasympathetic nervous system

ppm

Parts per million

Q10

Temperature coefficient

RQ

Respiratory quotient

SNS

Sympathetic nervous system

Ta

Ambient temperature

Tb

Body temperature

TMR

Torpid metabolic rate

TNZ

Thermoneutral zone

T1AM

3-Iodothyronamine

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Tulasi R. Jinka
    • 1
  • Zachary A. Barrickman
    • 2
  • Lori K. Bogren
    • 1
  • Trixie N. Lee
    • 1
  • Jasmine M. Olson
    • 1
  • Melanie M. Richter
    • 3
  • Brady M. Salli
    • 2
  • Timothy J. Stevenson
    • 2
  • Øivind Tøien
    • 1
  • C. Loren Buck
    • 2
  • Kelly L. Drew
    • 1
  1. 1.Institute of Arctic BiologyUniversity of Alaska FairbanksFairbanksUSA
  2. 2.Department of Biological SciencesUniversity of Alaska AnchorageAnchorageUSA
  3. 3.Department of Biology and WildlifeUniversity of Alaska FairbanksFairbanksUSA

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