Biofunctionalization of Surfaces Using Ultrathin Nanoscopic Collagen Matrices

  • Jens Friedrichs
  • Anna Taubenberger
  • Susanne Wegmann
  • David A. Cisneros
  • Clemens Franz
  • Daniel J. Müller


The biofunctionalization of materials creates interfaces on which proteins, cells, or tissues can fulfill native or desired tasks. Here we report how to control the assembly of type I collagen into well-defined nanoscopic matrices of different patterns. Collagen fibrils in these ultrathin (approximately 3 nm) matrices maintained their native structure as observed in vivo. This opens up the possibility to create programmable biofunctionalized matrices using collagen-binding proteins or proteins fused with collagen-binding domains. Applied to eukaryotic cells, these nanostructured matrices can direct cellular processes such as adhesion, orientation and migration.


Atomic Force Microscopy Collagen Fibril Collagen Matrix Collagen Molecule Collagen Matrice 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Jens Friedrichs
    • 1
  • Anna Taubenberger
    • 1
  • Susanne Wegmann
    • 1
  • David A. Cisneros
    • 1
  • Clemens Franz
    • 1
  • Daniel J. Müller
    • 1
  1. 1.Biotechnology CenterTechnische Universität DresdenDresdenGermany

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