S-Layer Proteins as Self-Assembly Tool in Nano Bio Technology

  • Melinda Varga
  • Nuriye Korkmaz


Surface (S-) layers are composed of (glyco) protein subunits that cover the outermost layer of some gram-negative, gram-positive bacteria and Archaea. The ability to self-assemble into monomolecular arrays in suspensions, on solid surfaces or on lipid films makes S-layers appealing for nanobiotechnology. Genetic engineering has opened up the possibility of generating functional tailored S-layer proteins. Production of ultrafiltration membranes, immobilization matrices, vaccine derivatives and functional lipid membranes are some of the applications of native and genetically modified S-layers. More interestingly, they have been recrystallized on various substrates such as silicon, glass or noble metals to be used in biosensor development. S-layers have also been used as templates for the production of regularly distributed nanoparticles and as ultrathin high-resolution resists in downscaling of electronic devices.


Protein Template Hafnium Oxide Geobacillus Stearothermophilus Guanidinium Hydrochloride Strain GL24 
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© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Institute of GeneticsTechnische Universität DresdenDresdenGermany

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