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Disappearance of Melanocytic Nevi

  • Vitaly TerushkinAffiliated withDermatology Service, Memorial Sloan-Kettering Cancer Center
  • , Ashfaq A. MarghoobAffiliated withMemorial Sloan-Kettering Skin Cancer Center Email author 
  • , Alon ScopeAffiliated withDermatology Service, Memorial Sloan-Kettering Cancer CenterDepartment of Dermatology, Sheba Medical CenterSackler Faculty of Medicine, Tel Aviv University
  • , Rainer Hofmann-WellenhofAffiliated withDepartment of Dermatology, Medical University of Graz

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Nevus involution is a common phenomenon, but the mechanisms responsible for this process are currently not well characterized. With the development of noninvasive imaging technologies, such as dermoscopy and reflectance confocal microscopy, we have begun to appreciate distinct morphological features that develop, or in some case, disappear during nevus involution. In this chapter, we describe several dermoscopic patterns of disappearing nevi and attempt to illustrate their potential mechanisms using evidence from the literature and personal experience.