A Novel Approach for Extracting Nociceptive-Related Time-Frequency Features in Event-Related Potentials

  • Li Hu
  • Weiwei Peng
  • Yong Hu
Part of the Advances in Intelligent and Soft Computing book series (AINSC, volume 145)


In the present study, we are mainly objective to develop a novel approach to extract nociceptive-related features in the time-frequency domain from the event-related potentials (ERPs) that were recorded using high-density EEG. First, the independent component analysis (ICA) was used to separate single-trial ERPs into a set of independent components (ICs), which were then clustered into three groups (symmetrically distributed ICs, non-symmetrically distributed ICs, and noise-related ICs). Second, the time-frequency distributions of each clustered group were calculated using continuous wavelet transform (CWT). Third, the principal component analysis (PCA) with varimax rotation was used to extract time-frequency features from all single-trial time-frequency distributions across all channels. Altogether, the developed approach would help effectively extracting nociceptive-related time-frequency features, thus yielding to an important contribution to the study of nociceptive-specific neural activities.


Independent Component Analysis Varimax Rotation Independent Component Analysis Continuous Wavelet Transform Laser Stimulus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Pfurtscheller, G., Lopes da Silva, F.H.: Event-related EEG/MEG synchronization and desynchronization: basic principles. Clin. Neurophysiol. 110, 1842–1857 (1999)CrossRefGoogle Scholar
  2. 2.
    Mouraux, A., Iannetti, G.D.: Across-trial averaging of event-related EEG responses and beyond. Magn. Reson. Imaging 26, 1041–1054 (2008)CrossRefGoogle Scholar
  3. 3.
    Ploner, M., et al.: Pain suppresses spontaneous brain rhythms. Cereb. Cortex 16, 537–540 (2006)CrossRefGoogle Scholar
  4. 4.
    Mouraux, A., et al.: Non-phase locked electroencephalogram (EEG) responses to CO2 laser skin stimulations reflect central interactions between A partial partial differential- and C-fibre afferent volleys. Clin. Neurophysiol. 114, 710–722 (2003)CrossRefGoogle Scholar
  5. 5.
    Ohara, S., et al.: Attention to a painful cutaneous laser stimulus modulates electrocorticographic event-related desynchronization in humans. Clin. Neurophysiol. 115, 1641–1652 (2004)CrossRefGoogle Scholar
  6. 6.
    Stancak, A., et al.: Desynchronization of cortical rhythms following cutaneous stimulation: effects of stimulus repetition and intensity, and of the size of corpus callosum. Clin. Neurophysiol. 114, 1936–1947 (2003)CrossRefGoogle Scholar
  7. 7.
    Iannetti, G.D., et al.: Determinants of laser-evoked EEG responses: pain perception or stimulus saliency? J. Neurophysiol. 100, 815–828 (2008)CrossRefGoogle Scholar
  8. 8.
    Del Percio, C., et al.: Distraction affects frontal alpha rhythms related to expectancy of pain: an EEG study. Neuroimage 31, 1268–1277 (2006)CrossRefGoogle Scholar
  9. 9.
    Mu, Y., et al.: Event-related theta and alpha oscillations mediate empathy for pain. Brain Res. 1234, 128–136 (2008)CrossRefGoogle Scholar
  10. 10.
    Bromm, B., Treede, R.D.: Laser-evoked cerebral potentials in the assessment of cutaneous pain sensitivity in normal subjects and patients. Rev. Neurol (Paris) 147, 625–643 (1991)Google Scholar
  11. 11.
    Iannetti, G.D., et al.: Usefulness of dorsal laser evoked potentials in patients with spinal cord damage: report of two cases. J. Neurol Neurosurg. Psychiatry 71, 792–794 (2001)CrossRefGoogle Scholar
  12. 12.
    Cruccu, G., et al.: Recommendations for the clinical use of somatosensory-evoked potentials. Clin. Neurophysiol. 119, 1705–1719 (2008)CrossRefGoogle Scholar
  13. 13.
    Bromm, B., Treede, R.D.: Nerve fibre discharges, cerebral potentials and sensations induced by CO2 laser stimulation. Hum. Neurobiol. 3, 33–40 (1984)Google Scholar
  14. 14.
    Carmon, A., et al.: Evoked cerebral responses to noxious thermal stimuli in humans. Exp. Brain. Res. 25, 103–107 (1976)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Orthopaedics and TraumatologyThe University of Hong KongHong KongChina
  2. 2.China Key Laboratory of Cognition and Personality and School of PsychologySouthwest UniversityChongqingChina

Personalised recommendations