Hyperlactatemia is considered a hallmark of ongoing tissue hypoxia, but this is not always the case, and erroneous conclusions may sometimes be drawn that lead to unjustified therapeutic interventions. In this note we discuss the possible implications of hyperlactatemia
KeywordsAcute Lung Injury Blood Lactate Lactic Acidosis Lactate Production Tissue Hypoxia
Unable to display preview. Download preview PDF.
- 2.Stacpoole PW, Wright EC, Baumgartner TG, Bersin RM, Buchalter S, Curry SH, Duncan CA, Harman EM, Henderson GN, Jenkinson S. A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group. N Engl J Med. 1992;327:1564–1569.Google Scholar
- 10.Rivers E, Nguyen B, Havstadt S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345(1368):1377.Google Scholar