Using ventilation-induced aortic pressure and flow variation to diagnose preload responsiveness

  • Michael R. Pinsky


The recent literature has documented that both arterial pulse pressure [1] and left ventricular stroke volume variations [2] induced by positive-pressure ventilation are sensitive and specific markers of preload responsiveness. The greater the degree of flow or pressure variation over the course of the respiratory cycle for a fixed tidal volume, the more likely the subject is to increase their cardiac output in response to a volume challenge and the greater that increase may be. Slama et al. [3] report in this issue that in a rabbit model of graded hemorrhage measuresof aortic flow variation during positive-pressureventilation cardiac output will increase in response to volume expansion. Furthermore


Pulse Pressure Variation Stroke Volume Variation Aortic Flow Pulmonary Artery Occlusion Pressure Arterial Pulse Pressure 
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© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Michael R. Pinsky
    • 1
  1. 1.Department of Intensive Care MedicineUniversity of Pittsburgh Medical CenterPittsburghUSA

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