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Variability of splanchnic blood flow measurements in patients with sepsis – physiology, pathophysiology or measurement errors?

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Applied Physiology in Intensive Care Medicine 2

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Abstract

Impaired tissue oxygenation, especially in the splanchnic region, may play a central role both in the pathogenesis of multiple organ dysfunction and in the development of complications in various groups of intensive care patients [1, 2]. In severe inflammation such as SIRS, septic infection, and septic shock, the metabolic demand for oxygen in the splanchnic region is increase [3, 4, 5]. This is explanied in part by and increased hepatic metabolism [6, 7]. In patients with normal or hyperdynamic hemodynamics, but the increase in oxygen consumption is disproportionate to the increase in blood flow.

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Author information

Authors and Affiliations

  1. Department of Intensive Care Medicine, University Hospital Bern, Bern, Switzerland

    S. M. Jakob

  2. Department of Intensive Care Medicine, University Hospital Bern (Inselspital), University of Bern, Bern, Switzerland

    J. Takala

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  1. S. M. Jakob
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  2. J. Takala
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Editor information

Editors and Affiliations

  1. Dept. of Critical Care Medicine, University of Pittsburgh Medical Center, Scaife Hall 606 3550 Terrace Street, Pittsburgh, PA, 15261, USA

    Michael R. Pinsky MD

  2. Dept. Intensive Care Medicine, Hôpital Henri Mondor, 51 av. Maréchal Lattre de Tassigny, 94010, Créteil, CX, France

    Laurent Brochard MD

  3. Dept. Intensive Care Medicine, Hospital de Sant Pau, Avda. S. Antonio M. Claret 167, 08025, Barcelona, Spain

    Jordi Mancebo MD

  4. General Intensive Care Unit, Università Cattolica des Sacro Cuore, Largo A. Gemelli 8, 00168, Rome, Italy

    Massimo Antonelli

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© 2012 Springer-Verlag Berlin Heidelberg

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Jakob, S.M., Takala, J. (2012). Variability of splanchnic blood flow measurements in patients with sepsis – physiology, pathophysiology or measurement errors?. In: Pinsky, M.R., Brochard, L., Mancebo, J., Antonelli, M. (eds) Applied Physiology in Intensive Care Medicine 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28233-1_33

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  • DOI: https://doi.org/10.1007/978-3-642-28233-1_33

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-28232-4

  • Online ISBN: 978-3-642-28233-1

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