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Red blood cell rheology in sepsis

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Applied Physiology in Intensive Care Medicine 2

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Abstract

Changes in red blood cell (RBC) function can contribute to alterations in microcirculatory blood flow and cellular dysoxia in sepsis. Decreases in RBC and neutrophil deformability impair the passage of these cells through the microcirculation. While the role of leukocytes has been the focus of many studies in sepsis, the role of erythrocyte rheological alterations in this syndrome has only recently been investigated. RBC rheology can be influenced by many factors, including alterations in intracellular calcium and adenosine triphosphate (ATP) concentrations, the effects of nitric oxide, a decrease in some RBC membrane components such as sialic acid, and an increase in others such as 2,3 diphosphoglycerate. Other factors include interactions with white blood cells and their products (reactive oxygen species), or the effects of temperature variations. Understanding the mechanisms of altered RBC rheology in sepsis, and the effects on blood flow and oxygen transport, may lead to improved patient management and reductions in morbidity and mortality.

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Author information

Authors and Affiliations

  1. Department of intensive care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium

    M. Piagnerelli

  2. Experimental Medicine Laboratory, André Vésale Hospital, Montigny-le-Tilleul, Belgium

    K. Zouaoui Boudjeltia & M. Vanhaeverbeek

  3. Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Route de Lennik, Brussels, Belgium

    J.-L. Vincent

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  1. M. Piagnerelli
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  2. K. Zouaoui Boudjeltia
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  3. M. Vanhaeverbeek
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  4. J.-L. Vincent
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Editors and Affiliations

  1. Dept. of Critical Care Medicine, University of Pittsburgh Medical Center, Scaife Hall 606 3550 Terrace Street, Pittsburgh, PA, 15261, USA

    Michael R. Pinsky MD

  2. Dept. Intensive Care Medicine, Hôpital Henri Mondor, 51 av. Maréchal Lattre de Tassigny, 94010, Créteil, CX, France

    Laurent Brochard MD

  3. Dept. Intensive Care Medicine, Hospital de Sant Pau, Avda. S. Antonio M. Claret 167, 08025, Barcelona, Spain

    Jordi Mancebo MD

  4. General Intensive Care Unit, Università Cattolica des Sacro Cuore, Largo A. Gemelli 8, 00168, Rome, Italy

    Massimo Antonelli

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Piagnerelli, M., Boudjeltia, K.Z., Vanhaeverbeek, M., Vincent, JL. (2012). Red blood cell rheology in sepsis. In: Pinsky, M.R., Brochard, L., Mancebo, J., Antonelli, M. (eds) Applied Physiology in Intensive Care Medicine 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28233-1_14

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