The Microarray Paradigm and Its Various Implementations
This short chapter, meant as a general introduction to the book, briefly retraces the development of DNA arrays in the early 1990s, the advent of actual microarrays in 1995 and the rapid development of expression profiling in the following years. A number of early references and some original illustrations provide the specific flavour of these beginnings. A discussion on why this technology was both sorely needed and technically within reach by this time leads to an outline of the current major types of DNA arrays and, beyond, on the implementation of this approach for proteins, peptides, tissues and other entities. Finally, the organisation of the book is briefly presented.
KeywordsProtein Array Tissue Array Microarray Approach Human Transcriptome Peptide Array
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