Nanomedicine in the Development of Drugs for Poverty-Related Diseases

  • Rose Hayeshi
  • Boitumelo Semete
  • Lonji Kalombo
  • Lebogang Katata
  • Yolandy Lemmer
  • Paula Melariri
  • Belle Nyamboli
  • Hulda Swai


The use of current treatments for poverty-related diseases (PRDs) is compromised due to factors such as toxicity and poor solubility leading to lowered bioavailability and thus reduced efficacy. In addition, there is lack of activity from the pharmaceutical industry due to the difficulty in refinancing the high development costs. Hence, new approaches have to be explored for the treatment of PRDs. Nanotechnology-based drug delivery systems (nanomedicine) offer a possible solution by presenting the ability to alter the pharmacokinetics of the conventional drugs to enhance bioavailability, increase the half-life of the drugs and reduce the toxicity. The advantages that nanomedicine-based drug delivery systems present in the treatment of PRDs and the progress of its application in Africa are summarised in this chapter. Nanodrug delivery systems seem to be a promising and viable strategy for improving treatment of PRDs and should urgently be considered in drug development programmes in Africa.


Human Immunodeficiency Virus Drug Delivery System Visceral Leishmaniasis PLGA Nanoparticles Drug Development Programme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Artemisinin-based combination therapies


Absorption, distribution, metabolism and excretion




Area under the curve


Maximum plasma concentration


Cytochrome P450








Human immunodeficiency virus






Minimum inhibitory concentration


Neglected tropical diseases






Polyethylene glycol




Poly(D,L-lactic-co-glycolic acid)


Poverty-related diseases




Reticuloendothelial system








Research and development




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Copyright information

© Springer Berlin Heidelberg 2012

Authors and Affiliations

  • Rose Hayeshi
    • 1
  • Boitumelo Semete
    • 1
  • Lonji Kalombo
    • 1
  • Lebogang Katata
    • 1
  • Yolandy Lemmer
    • 1
  • Paula Melariri
    • 1
  • Belle Nyamboli
    • 1
  • Hulda Swai
    • 1
  1. 1.Council for Scientific and Industrial Research, Polymers and CompositesPretoriaSouth Africa

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