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Overview of Current Drug Discovery Activities in Africa and Their Links to International Efforts to Combat Tropical Infectious Diseases

  • Barthélemy Nyasse
Chapter

Abstract

Africa’s drug discovery activities are largely shaped by the interests of international programs and funders, often not engaging with countries and their public health needs. These activities are also concentrated in countries where science and technologies receive significant attention as in South Africa, Tunisia, and Egypt. South Africa is incontestably the leader in drug discovery activities either on the basis of academic or pharmaceutical firms’ contributions in Africa. Capabilities do exist within Africa in the various drug discovery and development stages and commercialization for the following areas: basic and exploratory discovery research relevant to drugs, diagnostics, vaccines and insecticides, hit identification, hit to lead identification, lead optimization, natural products and traditional medicines, management of intellectual property, preclinical toxicology and safety pharmacology, clinical studies, regulatory expertise, process chemistry/ raw materials, manufacturing/formulation, and marketing and phase iv/pharmacovigilance. However, low levels of investment in science and technology and the lack of collaboration between key actors, a critical mass of drug scientists and a coordination of research activities, remain major challenges for the development of health innovation on the continent.

Keywords

Gross Domestic Product Visceral Leishmaniasis Southern African Development Community African Union Health Innovation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

AMANET

African Malaria Network

AMCOST

African Ministerial Council on Science and Technology

ANDI

African Network for Drugs and Diagnostics Innovation

API

Active Pharmaceutical Ingredients

APOC

African Programme for Onchocerciasis Control

APRIORI

African Poverty Related Infection Oriented Research Initiative

ASTIII

African Science, Technology and Innovation Indicators Initiative

ATPS

African Technology Policy Studies Network

AU

African Union

CARTA

Consortium for Advanced Research Training in Africa

CMH

Commission on Macroeconomics and Health

COHRED

Council on Health Research for Development

EDCTP

European and Developing Countries Clinical Trials Partnership

EMEA

European Medicines Agency

FDA

Food and Drug Administration

GATBDD

Global Alliance for TB Drug Development

GAVI

Global Alliance for Vaccines and Immunization

GDP

Gross Domestic Product

GHPs

Global Health Partnerships

GIBEX

Global Institute for BioExploration—Africa

GSPOA

Global Strategy and Plan of Action on Public Health, Innovation and Intellectual Property

HRP

Special Programme for Research and Training in Human Reproduction

HRSA WHO

Health Research Systems Analysis

HVI

HIV Vaccine Initiative

IAVI

International Aids Vaccine Initiative

ICGEB

International Centre for Genetic Engineering and Biotechnology

IGWG

Intergovernmental Working Group

IP

Intellectual Property

ISHReCA

Initiative to Strengthen Health Research Capacity in Africa

JSPS

Japan Society for the Promotion of Science

MCTA

Malaria Clinical Trials Alliance

MDGs

Millennium Development Goals

MDP

Mectizan Donation Programme

MMV

Medicines for Malaria Venture

MVI

Malaria Vaccine Initiative

NAPRECA

Natural Products Research Network of Eastern and Central Africa

NEPAD

New Partnership for Africa’s Development

OECD

Organisation for Economic Co-operation and Development

PDPPPs

Product Development Public-Private Partnerships

PEI

Polio Eradication Programme

PMPA

Pharmaceutical Manufacturing Plan for Africa

RBM

Roll Back Malaria

SACORE

Southern African Consortium for Research Excellence

SADC

Southern African development Community

SAMI

South African Malaria Initiative

SIGN

Safe Injection Global Network

TDR

Special Programme for Research and Training in Tropical Diseases

TRIPS

Trade and Related Aspects of Intellectual Property Rights

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Copyright information

© Springer Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Laboratory of Medicinal Chemistry and Pharmacognosy, Faculty of ScienceUniversity of Yaoundé IYaoundeCameroon

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