Size-Based Enrichment Technologies for CTC Detection and Characterization

  • Anthony Williams
  • Marija Balic
  • Ram Datar
  • Richard Cote
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 195)


The degree of metastatic outspread in malignant disease is one of the leading factors in determining the appropriate course treatment. Circulating tumor cells (CTCs) represent the population of cells that have acquired the means to gain access to the circulatory system, and the cell population ultimately responsible for the development of metastases at distant sites in the body. While promising as a biomarker for metastatic disease, the widespread study of CTCs has been limited by their rarity, as CTCs are reported to occur as infrequently as 1/mL of whole blood. In this text, we will discuss current and emerging technologies for the size-based enrichment of CTCs from whole blood, and compare some of the advantages and disadvantages of using a size-based approach to CTC enrichment versus affinity-based CTC enrichment platforms.


Circulate Tumor Cell Laser Capture Microdissection Castration Resistant Prostate Cancer Normal Healthy Donor Enrichment Technology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Anthony Williams
    • 1
  • Marija Balic
    • 2
  • Ram Datar
    • 1
  • Richard Cote
    • 1
  1. 1.Department of PathologyUniversity of Miami-Miller School of MedicineMiamiUSA
  2. 2.Division of Oncology, Department of Internal MedicineMedical University of GrazGrazAustria

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