• Elisabeth Ronne-Engström


There are no randomised, controlled, double-blind studies regarding treatment of early seizures after TBI, but from observational studies in the literature, there are good reasons to believe that seizures should be treated as soon as they occur. The basic idea with neurointensive care of TBI is to identify and treat conditions that compromise the brain’s supply and use of oxygen and glucose. Seizure activity in the acute phase impairs this in a number of ways and can therefore worsen the brain trauma. Neuronal firing causes a massive release of the potentially neurotoxic transmitter glutamate (GLU). In order to clear the synaptic space from GLU, there is an efficient glial uptake. However, this is highly energy dependent. Seizure activity can thus cause a significant increase in the energy demand, which can turn the brain into a manifest ischemia due to energy failure. Seizure activity can also cause significant changes in cerebral blood flow, with both increases and decreases observed.


Traumatic Brain Injury Status Epilepticus Seizure Activity Traumatic Brain Injury Patient Energy Failure 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of NeurosurgeryUppsala University HospitalUppsalaSweden

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