Personalized Image-Based Radiation Dosimetry for Routine Clinical Use in Peptide Receptor Radionuclide Therapy: Pretherapy Experience

  • Anna Celler
  • Joshua Grimes
  • Sergey Shcherbinin
  • Hanna Piwowarska-Bilska
  • Bozena Birkenfeld
Conference paper
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 194)


Patient-specific dose calculations are not routinely performed for targeted radionuclide therapy procedures, partly because they are time consuming and challenging to perform. However, it is becoming widely recognized that a personalized dosimetry approach can help plan treatment and improve understanding of the dose–response relationship. In this chapter, we review the procedures and essential elements of an accurate internal dose calculation and propose a simplified approach that is aimed to be practical for use in a busy nuclear medicine department.


Dose Distribution Dose Calculation Peptide Receptor Radionuclide Therapy Adaptive Threshold Biological Effective Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Anna Celler
    • 1
  • Joshua Grimes
    • 1
  • Sergey Shcherbinin
    • 1
  • Hanna Piwowarska-Bilska
    • 2
  • Bozena Birkenfeld
    • 2
  1. 1.Medical Imaging Research GroupUniversity of British Columbia, Vancouver Coastal Health Research InstituteVancouverCanada
  2. 2.Department of Nuclear MedicinePomeranian Medical UniversitySzczecinPoland

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