PRRT as Neoadjuvant Treatment in NET

  • Anna Sowa-Staszczak
  • Alicja Hubalewska-Dydejczyk
  • Monika Tomaszuk
Conference paper
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 194)


This chapter describes the possibility of using peptide receptor radionuclide therapy (PRRT) as neoadjuvant treatment. PRRT is acknowledged to be a palliative treatment. Recently it has been reported that tumor size decrease followed by surgical intervention might be achieved in patients with neuroendocrine tumors (NETs) treated with somatostatin analogs labeled with beta emitters. Such outcome of therapy has been described in a relatively small group of patients. In those patients, the treatment enabled total or partial excision of the tumor, also with liver metastases. Reduction of tumor dimensions or total excision of the tumor corresponded with prolongation of overall survival. The discussed papers on this subject differ in details of treatment (utilization of various isotopes, total activity of the isotope, or combination with radiosensitizing chemotherapy). The chapter presents a brief review of recently published manuscripts.


Liver Metastasis Peptide Receptor Radionuclide Therapy Pancreatic Tail Pancreatic Neuroendocrine Tumor Decrease Tumor Size 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Computed tomography

Ki index

Proliferation index


Neuroendocrine tumor


Positron emission tomography/computed tomography


Pancreatic neuroendocrine tumor


Peptide receptor radionuclide therapy


Response evaluation criteria for solid tumors


Single-photon emission computed tomography


Physical half-life




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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Anna Sowa-Staszczak
    • 1
  • Alicja Hubalewska-Dydejczyk
    • 1
  • Monika Tomaszuk
    • 1
  1. 1.Department of EndocrinologyJagiellonian University Medical CollegeKrakowPoland

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