Gynecological Cancers

  • Murat Beyzadeoglu
  • Gokhan Ozyigit
  • Ugur Selek
  • Ugur Selek
Chapter

Abstract

This book, arranged in an MCQ format complemented by oral exam questions, is designed to meet the needs of a wide range of examinees. Essential aspects of radiation physics, radiobiology, and clinical radiation oncology are well covered. Tumors at different sites are addressed in a series of individual chapters, and further chapters are devoted to lymphomas and total body irradiation, pediatric tumors, and rare tumors and benign diseases. The answer keys provide clear explanations for both the correct answers and incorrect statements.

Keywords

Cervical Cancer Endometrial Cancer Radical Hysterectomy Squamous Cell Cancer Endometrial Adenocarcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Safaeian M, Solomon D, Castle PE (2007) Cervical cancer prevention – cervical screening: science in evolution. Obstet Gynecol Clin North Am 34(4):739–760, ix. ReviewPubMedCrossRefGoogle Scholar
  2. 2.
    Silverberg SG, Ioffe OB (2003) Pathology of cervical cancer. Cancer J 9(5):335–347, ReviewPubMedCrossRefGoogle Scholar
  3. 3.
    Apgar BS, Zoschnick L, Wright TC Jr (2003) The 2001 Bethesda System terminology. Am Fam Physician 68(10):1992–1998, ReviewPubMedGoogle Scholar
  4. 4.
    American Joint Committee on Cancer (2010) Cervix uteri. In: Edge SB et al (eds) AJCC ­cancer staging manual, 7th edn. Springer, New York, p 395Google Scholar
  5. 5.
    Pecorelli S, Odicino F (2003) Cervical cancer staging. Cancer J 9(5):390–394, ReviewPubMedCrossRefGoogle Scholar
  6. 6.
    Hansen EK, Roach M III (2006) Handbook of evidence-based radiation oncology. Springer, New York, pp 338–339Google Scholar
  7. 7.
    Thomas GM (1999) Improved treatment for cervical cancer – concurrent chemotherapy and radiotherapy. N Engl J Med 340(15):1198–1200PubMedCrossRefGoogle Scholar
  8. 8.
    Pearcey R, Brundage M, Drouin P et al (2002) Phase III trial comparing radical radiotherapy with and without cisplatin chemotherapy in patients with advanced squamous cell cancer of the cervix. J Clin Oncol 20(4):966–972PubMedCrossRefGoogle Scholar
  9. 9.
    Rose PG, Bundy BN (2002) Chemoradiation for locally advanced cervical cancer: does it help? J Clin Oncol 20(4):891–893PubMedGoogle Scholar
  10. 10.
    Holtz DO, Dunton C (2002) Traditional management of invasive cervical cancer. Obstet Gynecol Clin North Am 29(4):645–657, ReviewPubMedCrossRefGoogle Scholar
  11. 11.
    Schlaerth AC, Abu-Rustum NR (2006) Role of minimally invasive surgery in gynecologic cancers. Oncologist 11(8):895–901, ReviewPubMedCrossRefGoogle Scholar
  12. 12.
    Usmani N, Foroudi F, Du J, Zakos C, Campbell H, Bryson P, Mackillop WJ (2005) An ­evidence-based estimate of the appropriate rate of utilization of radiotherapy for cancer of the cervix. Int J Radiat Oncol Biol Phys 63(3):812–827, Epub 2005 Jun 2. ReviewPubMedCrossRefGoogle Scholar
  13. 13.
    Eifel PJ, Burke TW, Delclos L et al (1991) Early stage I adenocarcinoma of the uterine cervix: treatment results in patients with tumors less than or equal to 4 cm in diameter. Gynecol Oncol 41(3):199–205PubMedCrossRefGoogle Scholar
  14. 14.
    Peters WA 3rd, Liu PY, Barrett RJ 2nd et al (2000) Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J Clin Oncol 18(8):1606–1613PubMedGoogle Scholar
  15. 15.
    Keys HM, Bundy BN, Stehman FB et al (1999) Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. N Engl J Med 340(15):1154–1161PubMedCrossRefGoogle Scholar
  16. 16.
    Whitney CW, Sause W, Bundy BN et al (1999) Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study. J Clin Oncol 17(5):1339–1348PubMedGoogle Scholar
  17. 17.
    Dusenbery KE, Gerbi BJ (2006) Radiation therapy for cervical cancer. In: Levitt SH, Purdy JA, Perez CA, Vijayakumar S (eds) Technical basis of radiation therapy. Springer, Berlin, p 585Google Scholar
  18. 18.
    Viswanathan AN, Petereit DG (2007) Gynecologic brachytherapy. In: Devlin PM (ed) Brachytherapy: applications and technique, 1st edn. Lippincott Williams & Wilkins, Philadelphia, pp 225–254Google Scholar
  19. 19.
    International Commission on Radiation Units and Measurements (1985) Dose and volume specification for reporting intracavitary therapy in gynecology, vol 38. International Commission on Radiation Units and Measurements, BethesdaGoogle Scholar
  20. 20.
    Wang KL, Yang YC, Chao KS, Wu MH, Tai HC, Chen TC, Huang MC, Chen JR, Su TH, Chen YJ (2007) Correlation of traditional point a with anatomic location of uterine artery and ureter in cancer of the uterine cervix. Int J Radiat Oncol Biol Phys 69(2):498–503PubMedCrossRefGoogle Scholar
  21. 21.
    Polyzos NP, Pavlidis N, Paraskevaidis E, Ioannidis JP (2006) Randomized evidence on chemotherapy and hormonal therapy regimens for advanced endometrial cancer: an overview of survival data. Eur J Cancer 42(3):319–326, Epub 2006 Jan 11. ReviewPubMedCrossRefGoogle Scholar
  22. 22.
    Zaino RJ, Kurman R, Herbold D et al (1991) The significance of squamous differentiation in endometrial carcinoma. Data from a Gynecologic Oncology Group study. Cancer 68(10):2293–2302PubMedCrossRefGoogle Scholar
  23. 23.
    American Joint Committee on Cancer (2010) Corpus uteri. In: Edge SB et al (eds) AJCC ­cancer staging manual, 7th edn. Springer, New York, p 403Google Scholar
  24. 24.
    Photopulos GJ (1994) Surgicopathologic staging of endometrial adenocarcinoma. Curr Opin Obstet Gynecol 6(1):92–97, ReviewPubMedGoogle Scholar
  25. 25.
    Tsukamoto N (1990) Surgical treatment of endometrial cancer. Gan No Rinsho 36(10):1149–1154, ReviewPubMedGoogle Scholar
  26. 26.
    Deeks E (2007) Local therapy in endometrial cancer: evidence based review. Curr Opin Oncol 19(5):512–515, ReviewPubMedCrossRefGoogle Scholar
  27. 27.
    Amant F, Moerman P, Neven P, Timmerman D, Van Limbergen E, Vergote I (2005) Endometrial cancer. Lancet 366(9484):491–505, ReviewPubMedCrossRefGoogle Scholar
  28. 28.
    Hansen EK, Roach M III (2006) Handbook of evidence-based radiation oncology. Springer, New York, pp 351–353Google Scholar
  29. 29.
    American Joint Committee on Cancer (2010) Vagina. In: Edge SB et al (eds) AJCC cancer staging manual, 7th edn. Springer, New York, p 387Google Scholar
  30. 30.
    Beyzadeoglu M, Ozyigit G, Ebruli C (2010) Basic radiation oncology, 1st edn. Springer, BerlinCrossRefGoogle Scholar
  31. 31.
    Greene FL, Page DL, Fleming ID et al; American Joint Committee on Cancer (2002) AJCC cancer staging manual, 6th edn. Springer, New YorkGoogle Scholar
  32. 32.
    Lukka H et al (2002) Concurrent cisplatin-based chemotherapy plus radiotherapy for cervical cancer: a meta-analysis. Clin Oncol (R Coll Radiol) 14(3):203–212CrossRefGoogle Scholar
  33. 33.
    Green JA et al (2001) Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis. Lancet 358(9284):781–786PubMedCrossRefGoogle Scholar
  34. 34.
    Landoni F et al (1997) Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer. Lancet 350(9077):535–540PubMedCrossRefGoogle Scholar
  35. 35.
    Rotman M et al (2006) A phase III randomized trial of postoperative pelvic irradiation in Stage IB cervical carcinoma with poor prognostic features: follow-up of a gynecologic oncology group study. Int J Radiat Oncol Biol Phys 65(1):169–176PubMedCrossRefGoogle Scholar
  36. 36.
    Rotman M et al (1995) Prophylactic extended-field irradiation of para-aortic lymph nodes in stages IIB and bulky IB and IIA cervical carcinomas Ten-year treatment results of RTOG 79-20. JAMA 274(5):387–393PubMedCrossRefGoogle Scholar
  37. 37.
    Chemoradiotherapy for Cervical Cancer Meta-analysis Collaboration (2008) Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: a systematic review and meta-analysis of individual patient data from 18 randomized trials. J Clin Oncol 26:5802–5812CrossRefGoogle Scholar
  38. 38.
    Scholten AN, van Putten WL, Beerman H, Smit VT, Koper PC, Lybeert ML et al (2005) Postoperative radiotherapy for Stage 1 endometrial carcinoma: long-term outcome of the randomized PORTEC trial with central pathology review. Int J Radiat Oncol Biol Phys 63(3):834–838PubMedCrossRefGoogle Scholar
  39. 39.
    Johnson N, Cornes P (2007) Survival and recurrent disease after postoperative radiotherapy for early endometrial cancer: systematic review and meta-analysis. BJOG 114(11):1313–1320PubMedCrossRefGoogle Scholar
  40. 40.
    Homesley HD, Bundy BN, Sedlis A, Adcock L (1986) Radiation therapy versus pelvic node resection for carcinoma of the vulva with positive groin nodes. Obstet Gynecol 68(6):733–740PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Murat Beyzadeoglu
    • 1
  • Gokhan Ozyigit
    • 2
  • Ugur Selek
    • 3
  • Ugur Selek
    • 4
  1. 1.Department of RadiationGulhane Military Medical SchoolEtlik, AnkaraTurkey
  2. 2.Department of Radiation Oncology Faculty of MedicineHacettepe UniversitySihhiye, AnkaraTurkey
  3. 3.MD Anderson Cancer CenterUniversity of TexasIstanbulTurkey
  4. 4.MD Anderson Radiation OncologyCenter at American Hospital-Istanbul NisantasiIstanbulTurkey

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