Genitourinary System Cancers

  • Gokhan Ozyigit
  • Murat Beyzadeoglu
  • Ugur Selek
  • Ugur Selek


This book, arranged in an MCQ format complemented by oral exam questions, is designed to meet the needs of a wide range of examinees. Essential aspects of radiation physics, radiobiology, and clinical radiation oncology are well covered. Tumors at different sites are addressed in a series of individual chapters, and further chapters are devoted to lymphomas and total body irradiation, pediatric tumors, and rare tumors and benign diseases. The answer keys provide clear explanations for both the correct answers and incorrect statements.


Prostate Cancer Bladder Cancer Gleason Score Testicular Cancer Prostatic Intraepithelial Neoplasia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Garnick MB (1993) Prostate cancer: screening, diagnosis, and management. Ann Intern Med 118(10):804–818PubMedGoogle Scholar
  2. 2.
    American Cancer Society (2008) Cancer facts and figures 2008. American Cancer Society, AtlantaGoogle Scholar
  3. 3.
    Augustin H, Erbersdobler A, Hammerer PG, Graefen M, Huland H (2004) Prostate cancers in the transition zone: Part 2; clinical aspects. BJU Int 94(9):1226–1229, ReviewPubMedCrossRefGoogle Scholar
  4. 4.
    Kurokawa K, Suzuki T, SuzukI K, Terada N, Ito K, Yoshikawa D, Arai Y, Yamanaka H (2003) Preliminary results of a monitoring system to confirm the preservation of cavernous nerves. Int J Urol 10(3):136–140PubMedCrossRefGoogle Scholar
  5. 5.
    Ali M, Johnson IP, Hobson J, Mohammadi B, Khan F (2004) Anatomy of the pelvic plexus and innervation of the prostate gland. Clin Anat 17(2):123–129PubMedCrossRefGoogle Scholar
  6. 6.
    Algaba F, Epstein JI, Aldape HC et al (1996) Assessment of prostate carcinoma in core needle biopsy–definition of minimal criteria for the diagnosis of cancer in biopsy material. Cancer 78(2):376–381PubMedCrossRefGoogle Scholar
  7. 7.
    Konishi N, Shimada K, Ishida E, Nakamura M (2005) Molecular pathology of prostate cancer. Pathol Int 55(9):531–539, ReviewPubMedCrossRefGoogle Scholar
  8. 8.
    Gleason DF (1977) Histologic grading and clinical staging of prostatic carcinoma. In: Tannenbaum M (ed) Urologic pathology: the prostate. Lea and Febiger, Philadelphia, pp 171–197Google Scholar
  9. 9.
    Reynolds MA, Kastury K, Groskopf J, Schalken JA, Rittenhouse H (2007) Molecular markers for prostate cancer. Cancer Lett 249(1):5–13, Epub 2007 Feb 15. ReviewPubMedCrossRefGoogle Scholar
  10. 10.
    Presti JR (2000) Neoplasm of the prostate gland. In: Tanagho EA, McAninch JW (eds) Smith’s general urology, 15th edn. The McGraw-Hill Companies, San Francisco, pp 399–421Google Scholar
  11. 11.
    Akyol F, Ozyigit G, Selek U, Karabulut E (2005) PSA bouncing after short term androgen deprivation and 3D-conformal radiotherapy for localized prostate adenocarcinoma and the relationship with the kinetics of testosterone. Eur Urol 48:40–45PubMedCrossRefGoogle Scholar
  12. 12.
    American Joint Committee on Cancer (2010) Prostate. In: Edge SB et al (eds) AJCC cancer staging manual, 7th edn. Springer, New York, p 457Google Scholar
  13. 13.
    Kiyoshima K, Yokomizo A, Yoshida T, Tomita K, Yonemasu H, Nakamura M, Oda Y, Naito S, Hasegawa Y (2004) Anatomical features of periprostatic tissue and its surroundings: a histological analysis of 79 radical retropubic prostatectomy specimens. Jpn J Clin Oncol 34(8):463–468PubMedCrossRefGoogle Scholar
  14. 14.
    Woods ME, Ouwenga M, Quek ML (2007) The role of pelvic lymphadenectomy in the management of prostate and bladder cancer. ScientificWorldJournal 7:789–799, ReviewPubMedCrossRefGoogle Scholar
  15. 15.
    Coleman RE (2007) Emerging strategies in bone health management for the adjuvant patient. Semin Oncol 34(6 Suppl 4):S11–S16, ReviewPubMedCrossRefGoogle Scholar
  16. 16.
    Hansen EK, Roach M III (2006) Handbook of evidence-based radiation oncology. Springer, New York, pp 297–298Google Scholar
  17. 17.
    Grubb RL 3rd, Vardi IY, Bhayani SB, Kibel AS (2006) Minimally invasive approaches to localized prostate carcinoma. Hematol Oncol Clin North Am 20(4):879–895, ReviewPubMedCrossRefGoogle Scholar
  18. 18.
    Villavicencio H, Segarra J (2006) Perineal prostatectomy. Ann Urol (Paris) 40(5):317–327, ReviewCrossRefGoogle Scholar
  19. 19.
    Roach M 3rd (2003) Hormonal therapy and radiotherapy for localized prostate cancer: who, where and how long? J Urol 170(6 Pt 2):S35–S40; discussion S40–S41. ReviewPubMedCrossRefGoogle Scholar
  20. 20.
    Khan FM (2007) Treatment planning in radiation oncology, 2nd edn. Lippincott Williams & Wilkins, Philadelphia, p 128Google Scholar
  21. 21.
    Fiks T, Sporny S (1985) Klinefelter’s syndrome and neoplasms. Wiad Lek 38(17):1223–1226, ReviewPubMedGoogle Scholar
  22. 22.
    Woodward PJ, Heidenreich A, Looijenga LHJ et al (2004) Germ cell tumours. In: Eble JN, Sauter G, Epstein JI et al (eds) Pathology and genetics of tumours of the urinary system and male genital organs. IARC Press, Lyon, pp 221–249Google Scholar
  23. 23.
    Bosl GJ, Bajorin DF, Sheinfeld J et al (2005) Cancer of the testis. In: DeVita VT Jr, Hellman S, Rosenberg SA (eds) Cancer: principles and practice of oncology, 7th edn. Lippincott Williams & Wilkins, Philadelphia, pp 1269–1290Google Scholar
  24. 24.
    Segal R, Lukka H, Klotz LH, Eady A, Bestic N, Johnston M, Cancer Care Ontario Practice Guidelines Initiative Genitourinary Cancer Disease Site Group (2001) Surveillance programs for early stage non-seminomatous testicular cancer: a practice guideline. Can J Urol 8(1):1184–1192, ReviewPubMedGoogle Scholar
  25. 25.
    American Joint Committee on Cancer (2010) Testis. In: Edge SB et al (eds) AJCC cancer staging manual, 7th edn. Springer, New York, p 469Google Scholar
  26. 26.
    Hansen EK, Roach M III (2006) Handbook of evidence-based radiation oncology. Springer, New York, p 328Google Scholar
  27. 27.
    Shabbir M, Morgan RJ (2004) Testicular cancer. J R Soc Health 124(5):217–218, ReviewCrossRefGoogle Scholar
  28. 28.
    Naysmith TE, Blake DA, Harvey VJ, Johnson NP (1998) Do men undergoing sterilizing cancer treatments have a fertile future? Hum Reprod 13(11):3250–3255PubMedCrossRefGoogle Scholar
  29. 29.
    Madeb R, Golijanin D, Knopf J, Messing EM (2007) Current state of screening for bladder cancer. Expert Rev Anticancer Ther 7(7):981–987, ReviewPubMedCrossRefGoogle Scholar
  30. 30.
    Mostofi FK, Davis CJ, Sesterhenn IA (1988) Pathology of tumors of the urinary tract. In: Skinner DG, Lieskovsky G (eds) Diagnosis and management of genitourinary cancer. Saunders, Philadelphia, pp 83–117Google Scholar
  31. 31.
    American Joint Committee on Cancer (2010) Urinary bladder. In: Edge SB et al (eds) AJCC cancer staging manual, 7th edn. Springer, New York, p 497Google Scholar
  32. 32.
    Soloway MS (1983) The management of superficial bladder cancer. In: Javadpour N (ed) Principles and management of urologic cancer, 2nd edn. Williams and Wilkins, Baltimore, pp 446–467Google Scholar
  33. 33.
    Epstein JI (2003) The new World Health Organization/International Society of Urological Pathology (WHO/ISUP) classification for TA, T1 bladder tumors: is it an improvement? Crit Rev Oncol Hematol 47(2):83–89, ReviewPubMedCrossRefGoogle Scholar
  34. 34.
    Hansen EK, Roach M III (2006) Handbook of evidence-based radiation oncology. Springer, New York, pp 286–287Google Scholar
  35. 35.
    Schulsinger AR, Allison RR, Choi WH (2006) Bladder cancer. In: Levitt SH, Purdy JA, Perez CA, Vijayakumar S (eds) Technical basis of radiation therapy. Springer, New York, pp 574–575Google Scholar
  36. 36.
    Beyzadeoglu M, Ozyigit G, Ebruli C (2010) Basic radiation oncology, 1st edn. Springer, BerlinCrossRefGoogle Scholar
  37. 37.
    Greene FL, Page DL, Fleming ID et al; American Joint Committee on Cancer (2002) AJCC cancer staging manual, 6th edn. Springer, New YorkGoogle Scholar
  38. 38.
    Francis R, Bower M, Brunström G et al (2000) Surveillance for stage I testicular germ cell tumours: results and cost benefit analysis of management options. Eur J Cancer 36(15):1925–1932PubMedCrossRefGoogle Scholar
  39. 39.
    Choo R, Thomas G, Woo T et al (2005) Long-term outcome of postorchiectomy surveillance for stage I testicular seminoma. Int J Radiat Oncol Biol Phys 61(3):736–740PubMedCrossRefGoogle Scholar
  40. 40.
    Oliver RT, Mason MD, Mead GM et al (2005) Radiotherapy versus single-dose carboplatin in adjuvant treatment of stage I seminoma: a randomised trial. Lancet 366(9482):293–300PubMedCrossRefGoogle Scholar
  41. 41.
    Fossa SD et al (1999) Optimal planning target volume for stage I testicular seminoma: A Medical Research Council randomized trial. Medical Research Council Testicular Tumor Working Group. J Clin Oncol 17(4):1146PubMedGoogle Scholar
  42. 42.
    Bolla M, van Poppel H, Collette L, van Cangh P, Vekemans K, Da Pozzo L et al (2005) Postoperative radiotherapy after radical prostatectomy: a randomised controlled trial (EORTC trial 22911). Lancet 366(9485):572–578PubMedCrossRefGoogle Scholar
  43. 43.
    Morgan SC, Walker-Dilks C, Goldman B, Eapen LJ, Winquist EW, Chin JL et al (2010) Does the benefit of adjuvant radiotherapy following radical prostatectomy for pathologic T3 or margin-positive prostate cancer extend to all pathologic subgroups? A meta-analysis of the randomized trials. Int J Radiat Oncol Biol Phys 78(3):29–30CrossRefGoogle Scholar
  44. 44.
    Selek U (2011) Testicular cancer. In: Lu JJ, Brady LW (eds) Decision making in radiation oncology. Springer, Berlin/Heidelberg, pp 628–635Google Scholar
  45. 45.
    Classen J, Schmidberger H, Meisner C, Souchon R, Sautter-Bihl ML, Sauer R et al (2003 Mar 15) Radiotherapy for stages IIA/B testicular seminoma: final report of a prospective multicenter clinical trial. J Clin Oncol 21(6):1101–1106PubMedCrossRefGoogle Scholar
  46. 46.
    Dosmann MA, Zagars GK (1993 Jun 15) Post-orchiectomy radiotherapy for stages I and II testicular seminoma. Int J Radiat Oncol Biol Phys 26(3):381–390PubMedCrossRefGoogle Scholar
  47. 47.
    Zagars GK, Pollack A (2001 Nov 1) Radiotherapy for stage II testicular seminoma. Int J Radiat Oncol Biol Phys 51(3):643–649PubMedCrossRefGoogle Scholar
  48. 48.
    Widmark A, Klepp O, Solberg A, Damber JE, Angelsen A, Fransson P et al (2009 Jan 24) Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial. Lancet 373(9660):301–308PubMedCrossRefGoogle Scholar
  49. 49.
    Mason MD, Warde PR, Sydes MR, Gospodarowicz MK, Swanson GP, Kirkbride P et al (2010) Intergroup randomized phase 3 study of androgen deprivation therapy (ADT) + radiation therapy (RT) in locally advanced prostate cancer (CaP) (NCIC-CTG, SWOG, MRC-UK, and INT: T94-0110; NCT00002633). Int J Radiat Oncol Biol Phys 78(3):2CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Gokhan Ozyigit
    • 1
  • Murat Beyzadeoglu
    • 2
  • Ugur Selek
    • 3
  • Ugur Selek
    • 4
  1. 1.Department of Radiation Oncology Faculty of MedicineHacettepe UniversitySihhiye, AnkaraTurkey
  2. 2.Department of RadiationGulhane Military Medical SchoolEtlik, AnkaraTurkey
  3. 3.MD Anderson Cancer CenterUniversity of TexasIstanbulTurkey
  4. 4.MD Anderson Radiation OncologyCenter at American Hospital-Istanbul NisantasiIstanbulTurkey

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