Breast Cancer

  • Gokhan Ozyigit
  • Murat Beyzadeoglu
  • Ugur Selek
  • Ugur Selek


This book, arranged in an MCQ format complemented by oral exam questions, is designed to meet the needs of a wide range of examinees. Essential aspects of radiation physics, radiobiology, and clinical radiation oncology are well covered. Tumors at different sites are addressed in a series of individual chapters, and further chapters are devoted to lymphomas and total body irradiation, pediatric tumors, and rare tumors and benign diseases. The answer keys provide clear explanations for both the correct answers and incorrect statements.


Latissimus Dorsi Muscle Pectoralis Muscle Invasive Ductal Cancer Invasive Lobular Cancer Pectoralis Minor Muscle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    American Cancer Society (2007) Cancer facts and figures 2007. American Cancer Society, AtlantaGoogle Scholar
  2. 2.
    American Joint Committee on Cancer (2010) Breast. In: Edge SB et al (eds) AJCC cancer staging manual, 6th edn. Springer, New York, p 347Google Scholar
  3. 3.
    Yeatman TJ, Cantor AB, Smith TJ et al (1995) Tumor biology of infiltrating lobular carcinoma. Implications for management. Ann Surg 222(4):549–559; discussion 559–561PubMedGoogle Scholar
  4. 4.
    Roddy HJ, Silverberg SG (1980) Ultrastructural analysis of apocrine carcinoma of the human breast. Ultrastruct Pathol 1:385–393PubMedCrossRefGoogle Scholar
  5. 5.
    Adler OB, Engel A (1990) Invasive lobular carcinoma. Mammographic pattern. Rofo 152(4):460–462PubMedCrossRefGoogle Scholar
  6. 6.
    Ackland SP, Bitran JD, Dowlatshahi K (1985) Management of locally advanced and inflammatory carcinoma of the breast. Surg Gynecol Obstet 161(4):399–408, ReviewPubMedGoogle Scholar
  7. 7.
    Valenzuela M, Julian TB (2007) Ductal carcinoma in situ: biology, diagnosis, and new therapies. Clin Breast Cancer 7(9):676–681, ReviewPubMedCrossRefGoogle Scholar
  8. 8.
    Hanby AM, Hughes TA (2008) In situ and invasive lobular neoplasia of the breast. Histopathology 52(1):58–66, ReviewPubMedCrossRefGoogle Scholar
  9. 9.
    Hansen EK, Roach M III (2006) Handbook of evidence-based radiation oncology. Springer, New York, pp 189–191Google Scholar
  10. 10.
    Lee MC, Jagsi R (2007) Postmastectomy radiation therapy: indications and controversies. Surg Clin North Am 87(2):511–526, xi. ReviewPubMedCrossRefGoogle Scholar
  11. 11.
    Pritchard KI, Shepherd LE, O’Malley FP et al (2006) HER2 and responsiveness of breast cancer to adjuvant chemotherapy. N Engl J Med 354(20):2103–2111PubMedCrossRefGoogle Scholar
  12. 12.
    Ueno NT, Buzdar AU, Singletary SE et al (1997) Combined-modality treatment of inflammatory breast carcinoma: twenty years of experience at M. D. Anderson Cancer Center. Cancer Chemother Pharmacol 40(4):321–329PubMedCrossRefGoogle Scholar
  13. 13.
    Weiss MC, Fowble BL, Solin LJ et al (1992) Outcome of conservative therapy for invasive breast cancer by histologic subtype. Int J Radiat Oncol Biol Phys 23(5):941–947PubMedCrossRefGoogle Scholar
  14. 14.
    Feller WF, Holt R, Spear S et al (1986) Modified radical mastectomy with immediate breast reconstruction. Am Surg 52(3):129–133PubMedGoogle Scholar
  15. 15.
    Whelan T, MacKenzie R, Julian J et al (2002) Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer. J Natl Cancer Inst 94(15):1143–1150PubMedCrossRefGoogle Scholar
  16. 16.
    Owen JR, Ashton A, Bliss JM et al (2006) Effect of radiotherapy fraction size on tumour control in patients with early-stage breast cancer after local tumour excision: long-term results of a randomised trial. Lancet Oncol 7(6):467–471PubMedCrossRefGoogle Scholar
  17. 17.
    Vicini FA, Sharpe M, Kestin L et al (2002) Optimizing breast cancer treatment efficacy with intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 54:1336–1344PubMedCrossRefGoogle Scholar
  18. 18.
    Beyzadeoglu M, Ozyigit G, Ebruli C (2010) Basic radiation oncology, 1st edn. Springer, BerlinCrossRefGoogle Scholar
  19. 19.
    Jatoi I, Kaufmann M, Petit JY (2006) Atlas of breast surgery. Springer, HeidelbergGoogle Scholar
  20. 20.
    Greene FL, Page DL, Fleming ID et al, American Joint Committee on Cancer (2002) AJCC cancer staging manual, 6th edn. Springer, New YorkGoogle Scholar
  21. 21.
    Taylor ME, Haffty BG, Rabinovitch R, Arthur DW, Halberg FE, Strom EA et al (2009) ACR appropriateness criteria on postmastectomy radiotherapy expert panel on radiation oncology-breast. Int J Radiat Oncol Biol Phys 73(4):997–1002PubMedCrossRefGoogle Scholar
  22. 22.
    Bartelink H, Horiot JC, Poortmans P, Struikmans H, Van den Bogaert W, Barillot I et al (2001) Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation. N Engl J Med 345(19):1378–1387PubMedCrossRefGoogle Scholar
  23. 23.
    Bartelink H, Horiot JC, Poortmans PM, Struikmans H, Van den Bogaert W, Fourquet A et al (2007) Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881–10882 trial. J Clin Oncol 25(22):3259–3265PubMedCrossRefGoogle Scholar
  24. 24.
    Romestaing P, Lehingue Y, Carrie C, Coquard R, Montbarbon X, Ardiet JM et al (1997) Role of a 10-Gy boost in the conservative treatment of early breast cancer: results of a randomized clinical trial in Lyon, France. J Clin Oncol 15(3):963–968PubMedGoogle Scholar
  25. 25.
    Halyard MY, Pisansky TM, Dueck AC, Suman V, Pierce L, Solin L et al (2009) Radiotherapy and adjuvant trastuzumab in operable breast cancer: tolerability and adverse event data from the NCCTG Phase III Trial N9831. J Clin Oncol 27(16):2638–2644PubMedCrossRefGoogle Scholar
  26. 26.
    Gennari A, Sormani MP, Pronzato P, Puntoni M, Colozza M, Pfeffer U et al (2008) HER2 status and efficacy of adjuvant anthracyclines in early breast cancer: a pooled analysis of randomized trials. J Natl Cancer Inst 100(1):14–20PubMedCrossRefGoogle Scholar
  27. 27.
    Krag DN, Anderson SJ, Julian TB, Brown AM, Harlow SP, Costantino JP et al (2010) Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in ­clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial. Lancet Oncol 11(10):927–933PubMedCrossRefGoogle Scholar
  28. 28.
    Rivers AK, Griffith KA, Hunt KK, Degnim AC, Sabel MS, Diehl KM et al (2006) Clinicopathologic features associated with having four or more metastatic axillary nodes in breast cancer patients with a positive sentinel lymph node. Ann Surg Oncol 13(1):36–44PubMedCrossRefGoogle Scholar
  29. 29.
    Giuliano AE, Hunt KK, Ballman KV, Beitsch PD, Whitworth PW, Blumencranz PW et al (2011) Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. JAMA 305(6):569–575PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Gokhan Ozyigit
    • 1
  • Murat Beyzadeoglu
    • 2
  • Ugur Selek
    • 3
  • Ugur Selek
    • 4
  1. 1.Department of Radiation Oncology Faculty of MedicineHacettepe UniversitySihhiye, AnkaraTurkey
  2. 2.Department of RadiationGulhane Military Medical SchoolEtlik, AnkaraTurkey
  3. 3.MD Anderson Cancer CenterUniversity of TexasIstanbulTurkey
  4. 4.MD Anderson Radiation OncologyCenter at American Hospital-Istanbul NisantasiIstanbulTurkey

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