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The membrane sources of macroautophagy

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Protein Quality Control in Neurodegenerative Diseases

Part of the book series: Research and Perspectives in Alzheimer's Disease ((ALZHEIMER))

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Abstract

Macroautophagy (hereafter called autophagy) is a catabolic, homeostatic process that is ubiquitous in eukaryotes and is conserved from yeast to human. The morphological hallmark of autophagy is the formation of cytosolic double-membrane vesicles that sequester cytoplasm and deliver it to the vacuole (the analog of the lysosome), where the cargos are degraded and the breakdown products are released through membrane permeases for reuse. Autophagy is connected to a wide range of pathophysiological conditions. Accordingly, it has attracted considerable attention in the last decade. A major, still unresolved, question concerns the origin of the membrane(s) that contribute to the formation of the autophagosome and the mechanism through which this compartment is generated.

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Authors and Affiliations

  1. Departments of Molecular, Cellular and Developmental Biology, Life Sciences Institute, University of Michigan, 210 Washtenaw Ave., Room 6036, Ann Arbor, MI, USA

    Daniel J. Klionsky, Melinda A. Lynch-Day, Jiefei Geng & Wei-Lien Yen

Authors
  1. Daniel J. Klionsky
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  2. Melinda A. Lynch-Day
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  3. Jiefei Geng
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  4. Wei-Lien Yen
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Corresponding author

Correspondence to Daniel J. Klionsky .

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Editors and Affiliations

  1. Morimoto Lab, Northwestern University, 2205 Tech Drive, Evanston, 60208-3500, Illinois, USA

    Richard I. Morimoto

  2. Fondation IPSEN, Quai Georges Gorse 65, Boulogne-Billancourt Cedex, 92650, France

    Yves Christen

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© 2013 Springer-Verlag Berlin Heidelberg

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Klionsky, D.J., Lynch-Day, M.A., Geng, J., Yen, WL. (2013). The membrane sources of macroautophagy. In: Morimoto, R., Christen, Y. (eds) Protein Quality Control in Neurodegenerative Diseases. Research and Perspectives in Alzheimer's Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27928-7_4

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