Proteostasis and the aging pathways

  • Ian Nicastro
  • Andrew Dillin
Part of the Research and Perspectives in Alzheimer's Disease book series (ALZHEIMER)


Aging is defined as the continuous accumulation of changes in an organism over time, arising intrinsically as well as through interaction with the environment. Some of these changes are harmful to the maintenance of homeostasis and render an individual more susceptible to diseases and disorders. Eventually, accumulation of enough of these changes negatively impacts an organism’s ability to respond to stresses and sets in motion a cascade of events that eventually ends in death. Aging is a universal condition that affects all life; however, different organisms age at remarkably different rates. This observation suggests that aging is not simply a stochastic response but instead has a powerful element of genetic mechanism. In seeking to understand why we age, there is potential for discovering strategies that might delay this inevitable process.


Dietary Restriction Ubiquitin Proteasome System Heat Shock Response Heat Shock Factor Life Span Extension 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Molecular and Cell Biology LaboratorySalk Institute for Biological StudiesLa JollaUSA

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