Skip to main content

Treatment of Coronary Artery Bifurcation Lesions

  • Chapter
  • First Online:
  • 3222 Accesses

Abstract

Optimal treatment of coronary bifurcation lesions is still the subject of debate.

Balloon angioplasty for this type of lesion used to be associated with a significant risk of acute complications compounded by a high risk of recurrent stenosis. With the advent of bare stents, the first controversies arose as to whether one or several stents should be used to treat these lesions. The outcome of various nonrandomized studies demonstrated the benefit of implementing a single-stent strategy whereby a stent is implanted in the main branch across the SB.

Drug-eluting stents allowed a considerable reduction in the risk of restenosis and repeat interventions while encouraging the development of numerous complex techniques permitting complete bifurcation coverage.

However, the results of large randomized studies confirmed the absence of benefits and even, in some instances, the inferiority of complex strategies compared with provisional SB stenting.

Recent comparative studies focusing on the most proximal coronary bifurcation, namely, the distal left main, have shown that PCI seems to be as efficient and safe as bypass surgery in this setting.

Over the past few years, a large number of stents dedicated to the treatment of bifurcation lesions have been developed with the main objective of allowing treatment of these complex lesions by all operators. The first randomized study comparing a dedicated device to a provisional side branch stenting approach using workhorse stents is currently underway.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Kassab GS (2005) Functional hierarchy of coronary circulation: direct evidence of a structure-function relation. Am J Physiol Heart Circ Physiol 289(6):H2559–H2565

    Article  PubMed  CAS  Google Scholar 

  2. Kassab GS (2007) Design of coronary circulation: the minimum energy hypothesis. Comput Methods Appl Mech Eng 196:3033–3042

    Article  Google Scholar 

  3. Kamiya A, Takahashi T (2007) Quantitative assessments of morphological and functional properties of biological trees based on their fractal nature. J Appl Physiol 102(6):2315–2323

    Article  PubMed  Google Scholar 

  4. Murray CD (1926) The physiological principle of minimum work: I. The vascular system and the cost of blood volume. Proc Natl Acad Sci USA 12:207–214

    Article  PubMed  CAS  Google Scholar 

  5. Huo Y, Kassab GS (2009) A scaling law of vascular volume. Biophys J 96(2):347–353

    Article  PubMed  CAS  Google Scholar 

  6. Finet G, Gilard M, Perrenot B et al (2008) Fractal geometry of cornary bifurcations: a quantitative coronary angiography and intravascular ultrasound analysis. EuroIntervention 3:490–498

    Article  PubMed  Google Scholar 

  7. Choy JS, Kassab GS (2008) Scaling of myocardial mass to flow and morphometry of coronary arteries. J Appl Physiol 104(5):1259

    Article  Google Scholar 

  8. Asakura T, Karino T (1990) Flow patterns and spatial distribution of atherosclerotic lesions in human coronary arteries. Circ Res 66(4):1045–1066

    Article  PubMed  CAS  Google Scholar 

  9. Chatzizisis YS, Jonas M, Coskun AU et al (2008) Prediction of the localization of high-risk coronary atherosclerotic plaques on the basis of low endothelial shear stress: an intravascular ultrasound and histopathology natural history study. Circulation 117(8):993–1002

    Article  PubMed  Google Scholar 

  10. Joner M, Finn AV, Farb A, Mont EK et al (2006) Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk. J Am Coll Cardiol 48(1):193–202

    Article  PubMed  Google Scholar 

  11. Shimada Y, Courtney BK, Nakamura M et al (2006) Intravascular ultrasonic analysis of atherosclerotic vessel remodeling and plaque distribution of stenotic left anterior descending coronary arterial bifurcation lesions upstream and downstream of the side branch. Am J Cardiol 98(2):193–196

    Article  PubMed  Google Scholar 

  12. van der Giessen AG, Wentzel JJ, Meijboom WB et al (2009) Plaque and shear stress distribution in human coronary bifurcations: a multislice computed tomography study. EuroIntervention 4(5):654–661

    Article  PubMed  Google Scholar 

  13. Medina A, Martín P, de Suárez Lezo J et al (2011) Ultrasound study of the prevalence of plaque at the carina in lesions that affect the coronary bifurcation. Implications for treatment with provisional stent. Rev Esp Cardiol 64(1):43–50

    Article  PubMed  Google Scholar 

  14. Nakazawa G, Yazdani SK, Finn AV et al (2010) Pathological findings at bifurcation lesions: the impact of flow distribution on atherosclerosis and arterial healing after stent implantation. J Am Coll Cardiol 55(16):1679–1687

    Article  PubMed  Google Scholar 

  15. Ahmed JM, Mintz GS, Weissman NJ et al (2000) Mechanism of lumen enlargement during intracoronary stent implantation: an intravascular ultrasound study. Circulation 102(1):7–10

    Article  PubMed  CAS  Google Scholar 

  16. Koo BK, Waseda K, Kang HJ et al (2010) Anatomic and functional evaluation of bifurcation lesions undergoing percutaneous coronary intervention. Circ Cardiovasc Interv 3(2):113–119

    Article  PubMed  Google Scholar 

  17. Saucedo JF, Mehran R, Dangas G et al (2000) Long-term clinical events following creatine kinase–myocardial band isoenzyme elevation after successful coronary stenting. J Am Coll Cardiol 35(5):1134–1141

    Article  PubMed  CAS  Google Scholar 

  18. Bhargava B, Waksman R, Lansky AJ et al (2001) Clinical outcomes of compromised side branch [stent jail] after coronary stenting with the NIR stent. Catheter Cardiovasc Interv 54:295–300

    Article  PubMed  CAS  Google Scholar 

  19. Louvard Y, Thomas M, Dzavik V et al (2008) Classification of coronary artery bifurcation lesions and treatments: time for a consensus! Catheter Cardiovasc Interv 71(2):175–183

    Article  PubMed  Google Scholar 

  20. Koller P, Safian RD (1996) Bifurcation stenosis in manual of interventional cardiology. Physician’s Press, Birmingham, pp 229–241

    Google Scholar 

  21. Spokojny AM, Sanborn TM (1996) The bifurcation lesion. In: Ellis SG, Holmes DR (eds) Strategic approaches in coronary intervention. Williams and Wilkins, Baltimore, p 288

    Google Scholar 

  22. Topol EJ (1999) Textbook of interventional cardiology, 3rd edn. W.B. Saunders, Philadelphia

    Google Scholar 

  23. Lefèvre T, Louvard Y, Morice MC et al (2000) Stenting of bifurcation lesions: classification, treatments, and results. Catheter Cardiovasc Interv 49:274–283

    Article  PubMed  Google Scholar 

  24. Safian RD (2001) Bifurcation lesions. In: Safian RD, Freed MS (eds) The manual of interventional cardiology. Physician’s Press, Royal Oak, p 222

    Google Scholar 

  25. Hoye A, van Mieghem CA, Ong AT et al (2005) Treatment of de novo bifurcation lesions: a comparison of Sirolimus- and Paclitaxel-eluting stents. EuroIntervention 1(1):24–30

    PubMed  Google Scholar 

  26. Medina A, de Suarez Lezo J, Pan M (2006) A new classification of coronary bifurcation lesions. Rev Esp Cardiol 59:183

    Article  PubMed  Google Scholar 

  27. Movahed MR, Stinis CT (2006) A new proposed simplified classification of coronary artery bifurcation lesions and bifurcation interventional techniques. J Invasive Cardiol 18:199–204

    PubMed  Google Scholar 

  28. Andriotis A, Zifan A, Gavaises M et al (2008) A new method of three-dimensional coronary artery reconstruction from X-ray angiography: validation against a virtual phantom and multislice computed tomography. Catheter Cardiovasc Interv 71(1):28–43

    Article  PubMed  Google Scholar 

  29. Pflederer T, Ludwig J, Ropers D et al (2006) Measurement of coronary artery bifurcation angles by multidetector computed tomography. Invest Radiol 41(11):793–798

    Article  PubMed  Google Scholar 

  30. Lansky A, Tuinenburg J, Costa M, European Bifurcation Angiographic Sub-Committee et al (2009) Quantitative angiographic methods for bifurcation lesions: a consensus statement from the European Bifurcation Group. Catheter Cardiovasc Interv 73(2):258–266

    Article  PubMed  Google Scholar 

  31. Goktekin O, Kaplan S, Dimopoulos K et al (2007) A new quantitative analysis system for the evaluation of coronary bifurcation lesions: comparison with current conventional methods. Catheter Cardiovasc Interv 69(2):172–180

    Article  PubMed  Google Scholar 

  32. Ramcharitar S, Onuma Y, Aben JP et al (2008) A novel dedicated quantitative coronary analysis methodology for bifurcation analysis. EuroIntervention 3:553–557

    Article  PubMed  Google Scholar 

  33. Holm NR, Højdahl H, Lassen JF et al (2011) Quantitative coronary analysis in the Nordic Bifurcation studies. Int J Cardiovasc Imaging 27:175–180, Epub 2010 Oct 7

    Article  PubMed  Google Scholar 

  34. Furukawa E, Hibi K, Kosuge M, Nakatogawa T, Toda N, Takamura T, Tsukahara K, Okuda J, Ootsuka F, Tahara Y, Sugano T, Endo T, Kimura K, Umemura S (2005) Intravascular ultrasound predictors of side branch occlusion in bifurcation lesions after percutaneous coronary intervention. Circ J 69(3):325–330

    Article  PubMed  Google Scholar 

  35. Oviedo C, Maehara A, Mintz GS, Tsujita K, Kubo T, Doi H, Castellanos C, Lansky AJ, Mehran R, Dangas G, Leon MB, Stone GW, Templin B, Araki H, Ochiai M, Moses JW (2010) Is accurate intravascular ultrasound evaluation of the left circumflex ostium from a left anterior descending to left main pullback possible? Am J Cardiol 105(7):948–954

    Article  PubMed  Google Scholar 

  36. Tyczynski P, Ferrante G, Moreno-Ambroj C, Kukreja N, Barlis P, Pieri E, De Silva R, Beatt K, Di Mario C (2010) Simple versus complex approaches to treating coronary bifurcation lesions: direct assessment of stent strut apposition by optical coherence tomography. Rev Esp Cardiol 63(8):904–914

    Article  PubMed  Google Scholar 

  37. Tonino PA, De Bruyne B, Pijls NH, Siebert U, Ikeno F, van Veer M, Klauss V, Manoharan G, Engstrøm T, Oldroyd KG, Ver Lee PN, MacCarthy PA, Fearon WF, FAME Study Investigators (2009) Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med 360(3):213–224

    Article  PubMed  CAS  Google Scholar 

  38. Sarno G, Garg S, Onuma Y et al (2010) Bifurcation lesions: functional assessment by fractional flow reserve vs. anatomical assessment using conventional and dedicated bifurcation quantitative coronary angiogram. Catheter Cardiovasc Interv 76(6):817–823

    Article  PubMed  Google Scholar 

  39. Louvard Y, Lefèvre T, Morice MC (2004) Percutaneous coronary intervention for bifurcation coronary disease. Heart 90(6):713–722, Review

    Article  PubMed  Google Scholar 

  40. Yamashita T, Nishida T, Adamian MG et al (2000) Bifurcation lesions: two stents versus one stent-immediate and follow-up results. J Am Coll Cardiol 35:1145–1151

    Article  PubMed  CAS  Google Scholar 

  41. Colombo A, Moses JW, Morice MC et al (2004) Randomized study to evaluate sirolimus-eluting stents implanted at coronary bifurcation lesions. Circulation 109:1244–1249

    Article  PubMed  Google Scholar 

  42. Pan M, de Lezo JS, Medina A, Romero M et al (2004) Rapamycin-eluting stents for the treatment of bifurcated coronary lesions: a randomized comparison of a simple versus complex strategy. Am Heart J 148(5):857–864

    Article  PubMed  CAS  Google Scholar 

  43. Steigen TK, Maeng M, Wiseth R, Erglis A et al (2006) Randomized study on simple versus complex stenting of coronary artery bifurcation lesions: the Nordic bifurcation study. Nordic PCI Study Group. Circulation 114(18):1955–1961

    Article  PubMed  Google Scholar 

  44. Ferenc M, Gick M, Kienzle RP, Bestehorn HP et al (2008) Randomized trial on routine vs. provisional T-stenting in the treatment of de novo coronary bifurcation lesions. Eur Heart J 29(23):2859–2867

    Article  PubMed  Google Scholar 

  45. Colombo A, Bramucci E, Saccà S et al (2009) Randomized study of the crush technique versus provisional side-branch stenting in true coronary bifurcations: the CACTUS (Coronary Bifurcations: Application of the Crushing Technique Using Sirolimus-Eluting Stents) Study. Circulation 119(1):71–78

    Article  PubMed  Google Scholar 

  46. Hildick-Smith D, De Belder AJ, Cooter N et al (2010) Randomized trial of simple versus complex drug-eluting stenting for bifurcation lesions: the British bifurcation coronary study: old, new, and evolving strategies. Circulation 121:1235–1243

    Article  PubMed  CAS  Google Scholar 

  47. Chen SL, Santoso T, Zhang JJ, Ye F, Xu YW, Fu Q, Kan J, Paiboon C, Zhou Y, Ding SQ, Kwan TW (2011) A randomized clinical study comparing double kissing crush with provisional stenting for treatment of coronary bifurcation lesions results from the DKCRUSH-II (double kissing crush versus provisional stenting technique for treatment of coronary bifurcation lesions) trial. J Am Coll Cardiol 57(8):914–920

    Article  PubMed  Google Scholar 

  48. Cheng WJ, Zhou YJ, Zhao YX et al (2010) Randomized study on T stenting and small protrusion technique versus simple stenting for patients with coronary artery bifurcation lesions and with big size side branch. Zhonghua Xin Xue Guan Bing Za Zhi 38(2):131–134

    PubMed  Google Scholar 

  49. Erglis A, Kumsars I, Niemelä M, Nordic PCI Study Group et al (2009) Randomized comparison of coronary bifurcation stenting with the crush versus the culotte technique using sirolimus eluting stents: the Nordic stent technique study. Circ Cardiovasc Interv 2(1):27–34

    Article  PubMed  Google Scholar 

  50. Pan M, Medina A, de Suárez Lezo J, Romero M, Segura J, Martín P, Hernández E, Mazuelos F, Moreno A, Pavlovic D, Ojeda S, Toledano F, Leon C (2011) Coronary bifurcation lesions treated with simple approach (from the Cordoba & Las Palmas [CORPAL] Kiss Trial). Am J Cardiol 107(10):1460–1465

    Article  PubMed  Google Scholar 

  51. Niemelä M, Kervinen K, Erglis A, Nordic-Baltic PCI Study Group et al (2011) Randomized comparison of final kissing balloon dilatation versus no final kissing balloon dilatation in patients with coronary bifurcation lesions treated with main vessel stenting: the Nordic-Baltic Bifurcation Study III. Circulation 123(1):79–86

    Article  PubMed  Google Scholar 

  52. Pan M, de Suárez Lezo J, Medina A et al (2007) Drug-eluting stents for the treatment of bifurcation lesions: a randomized comparison between paclitaxel and sirolimus stents. Am Heart J 153(1):15.e1–15.e7

    Article  Google Scholar 

  53. Iakovou I, Schmidt T, Bonizzoni E et al (2005) Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents. JAMA 293(17):2126–2130

    Article  PubMed  CAS  Google Scholar 

  54. Ong AT, McFadden EP, Regar E et al (2005) Late angiographic stent thrombosis (LAST) events with drug-eluting stents. J Am Coll Cardiol 45(12):2088–2092

    Article  PubMed  CAS  Google Scholar 

  55. Kuchulakanti PK, Chu WW, Torguson R et al (2006) Correlates and long-term outcomes of angiographically proven stent thrombosis with sirolimus- and paclitaxel-eluting stents. Circulation 113(8):1108–1113

    Article  PubMed  CAS  Google Scholar 

  56. Kozuma K, Ota Y, Nagai Y et al (2011) Clinical and angiographic outcomes with sirolimus-eluting stent for coronary bifurcation lesions. Circ J 75(2):306–314

    Article  PubMed  Google Scholar 

  57. Hakeem A, Khan FM, Bhatti S et al (2009) Provisional vs. complex stenting strategy for coronary bifurcation lesions: meta-analysis of randomized trials. Invasive Cardiol 21(11):589–595

    Google Scholar 

  58. Katritsis DG, Siontis GC, Ioannidis JP (2009) Double versus single stenting for coronary bifurcation lesions: a meta-analysis. Circ Cardiovasc Interv 2(5):409–415

    Article  PubMed  Google Scholar 

  59. Brar SS, Gray WA, Dangas G et al (2009) Bifurcation stenting with drug-eluting stents: a systematic review and meta-analysis of randomised trials. EuroIntervention 5(4):475–484

    Article  PubMed  Google Scholar 

  60. Biondi-Zoccai G (2010) Duplicate meta-analyses on coronary bifurcation strategies: when more is less? EuroIntervention 6(2):181–183

    Article  PubMed  Google Scholar 

  61. Zhang F, Dong L, Ge J (2009) Simple versus complex stenting strategy for coronary artery bifurcation lesions in the drug-eluting stent era: a meta-analysis of randomised trials. Heart 95(20):1676–1681, Review

    Article  PubMed  CAS  Google Scholar 

  62. Behan MW, Holm NR, Curzen NP et al (2011) Simple or complex stenting for bifurcation coronary lesions: a patient-level pooled-analysis of the Nordic Bifurcation Study and the British Bifurcation Coronary Study. Circ Cardiovasc Interv 4:57–64

    Article  PubMed  Google Scholar 

  63. Niccoli G, Ferrante G, Porto I et al (2010) Coronary bifurcation lesions: to stent one branch or both? A meta-analysis of patients treated with drug eluting stents. Int J Cardiol 139(1):80–91

    Article  PubMed  Google Scholar 

  64. Athappan G, Ponniah T, Jeyaseelan L (2010) True coronary bifurcation lesions: meta-analysis and review of literature. J Cardiovasc Med (Hagerstown) 11(2):103–110, review

    Article  Google Scholar 

  65. Zamani P, Kinlay S (2010) Long-term risk of clinical events from stenting side-branches of coronary bifurcation lesions with drug-eluting and bare-metal stents: an observational meta-analysis. Catheter Cardiovasc Interv 77:202–212

    Article  Google Scholar 

  66. Louvard Y, Lefèvre T, Cherukupalli R et al (2003) Favorable effect of the “jailed wire” technique when stenting bifurcation lesions. Am J Cardiol 6 (Abstr. Supp)

    Google Scholar 

  67. Brunel P, Lefevre T, Darremont O et al (2006) Provisional T-stenting and kissing balloon in the treatment of coronary bifurcation lesions: results of the French multicenter “TULIPE” study. Catheter Cardiovasc Interv 68(1):67–73

    Article  PubMed  Google Scholar 

  68. Burzotta F, de Vita M, Sgueglia G et al (2010) How to solve difficult SB access? EuroIntervention Suppl 6(suppl J):J72–J80

    Article  Google Scholar 

  69. Lefevre T, Darremont O, Albiero R (2010) Provisional side branch stenting for the treatment of bifurcation lesions. EuroIntervention Suppl 6(suppl J):J65–J71

    Article  Google Scholar 

  70. Burzotta F, Trani C, Sianos G (2010) Jailed balloon protection: a new technique to avoid acute side-branch occlusion during provisional stenting of bifurcated lesions. Bench test report and first clinical experience. EuroIntervention 5(7):809–813

    Article  PubMed  Google Scholar 

  71. Furuichi S, Airoldi F, Colombo A (2007) Rescue inverse crush: a way of get out of trouble. Catheter Cardiovasc Interv 70(5):708–712

    Article  PubMed  Google Scholar 

  72. Koo BK, Kang HJ, Youn TJ et al (2005) Physiologic assessment of jailed side branch lesions using fractional flow reserve. J Am Coll Cardiol 46(4):633–637

    Article  PubMed  Google Scholar 

  73. Adriaenssens T, Byrne RA, Dibra A et al (2008) Culotte stenting technique in coronary bifurcation disease: angiographic follow-up using dedicated quantitative coronary angiographic analysis and 12-month clinical outcomes. Eur Heart J 29(23):2868–2876

    Article  PubMed  Google Scholar 

  74. Colombo A, Stankovic G, Orlic D et al (2003) Modified T-stenting technique with crushing for bifurcation lesions: immediate results and 30-day outcome. Catheter Cardiovasc Interv 60(2):145–151

    Article  PubMed  CAS  Google Scholar 

  75. Chevalier B, Glatt B, Royer T et al (1998) Placement of coronary stents in bifurcation lesions by the “culotte” technique. Am J Cardiol 82:943–949

    Article  PubMed  CAS  Google Scholar 

  76. Sharma SK, Choudhury A, Lee J, Kim MC, Fisher E, Steinheimer AM, Kini AS (2004) Simultaneous kissing stents (SKS) technique for treating bifurcation lesions in medium-to-large arteries. Am J Cardiol 94(7):913–917

    Article  PubMed  Google Scholar 

  77. Sharma SK (2005) Simultaneous kissing drug-eluting stent technique for percutaneous treatment of bifurcation lesions in large-size vessels. Catheter Cardiovasc Interv 65(1):10–16

    Article  PubMed  Google Scholar 

  78. Ge L, Airoldi F, Iakovou I et al (2005) Clinical and angiographic outcome after implantation of drug-eluting stents in bifurcation lesions with the crush stent technique: importance of final kissing balloon post-dilation. J Am Coll Cardiol 46:613–620

    Article  PubMed  CAS  Google Scholar 

  79. Kim YH, Park SW, Hong MK et al (2006) Comparison of simple and complex stenting techniques in the treatment of unprotected left main coronary artery bifurcation stenosis. Am J Cardiol 97(11):1597–1601

    Article  PubMed  Google Scholar 

  80. Palmerini T, Marzocchi A, Tamburino C et al (2008) Impact of bifurcation technique on 2-year clinical outcomes in 773 patients with distal unprotected left main coronary artery stenosis treated with drug-eluting stents. Circ Cardiovasc Interv 1(3):185–192

    Article  PubMed  Google Scholar 

  81. Toyofuku M, Kimura T, Morimoto T, j-Cypher Registry Investigators et al (2009) Three-year outcomes after sirolimus-eluting stent implantation for unprotected left main coronary artery disease: insights from the j-Cypher registry. Circulation 120(19):1866–1874

    Article  PubMed  Google Scholar 

  82. Ikeno F, Kim YH, Luna J et al (2006) Acute and long-term outcomes of the novel side access (SLK-View) stent for bifurcation coronary lesions: a multicenter nonrandomized feasibility study. Catheter Cardiovasc Interv 67(2):198–206

    Article  PubMed  Google Scholar 

  83. Lefèvre T, Ormiston J, Guagliumi G et al (2005) The Frontier stent registry: safety and feasibility of a novel dedicated stent for the treatment of bifurcation coronary artery lesions. J Am Coll Cardiol 46(4):592–598

    Article  PubMed  Google Scholar 

  84. Garcia del Blanco G, Bellera Gotarda N, Marti G et al (2011) Clinical and procedural evaluation of the Nile Croco dedicated stent fopr bifurcation. Results of one center initial experience with the first 151 consecutive non-selected patients. EuroIntervention (in press)

    Google Scholar 

  85. Ormiston JA, Lefèvre T, Grube E et al (2010) First human use of the TAXUS Petal paclitaxel-eluting bifurcation stent. EuroIntervention 6(1):46–53

    Article  PubMed  Google Scholar 

  86. Sorop O, Hatten TR, van Beusekorn H et al (2010) Dedicated Everolimus-eluting side branch access system: XIENCE SBA. EuroIntervention Suppl 6(suppl J):J155–J160

    Article  Google Scholar 

  87. Cervinka P, Bystron M, Spacek R et al (2008) Treatment of bifurcation lesions using dedicated bifurcation stents versus classic bare-metal stents. Randomized, controlled trial with 12-month angiographic follow up. J Invasive Cardiol 20(10):516–520

    PubMed  Google Scholar 

  88. Verheye S, Grube E, Ramcharitar S et al (2009) First-in-man (FIM) study of the Stentys bifurcation stent–30 days results. EuroIntervention 4(5):566–571

    Article  PubMed  Google Scholar 

  89. Verheye S, Agostoni P, Dubois CL et al (2009) 9-month clinical, angiographic, and intravascular ultrasound results of a prospective evaluation of the Axxess self-expanding biolimus A9-eluting stent in coronary bifurcation lesions: the DIVERGE (Drug-Eluting Stent Intervention for Treating Side Branches Effectively) study. J Am Coll Cardiol 53(12):1031–1039

    Article  PubMed  Google Scholar 

  90. Onuma Y, Müller R, Ramcharitar S et al (2008) Tryton I, First-In-Man (FIM) study: six month clinical and angiographic outcome, analysis with new quantitative coronary angiography dedicated for bifurcation lesions. EuroIntervention 3(5):546–552

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yves Louvard M.D., FSCAI .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Louvard, Y., Lefèvre, T. (2013). Treatment of Coronary Artery Bifurcation Lesions. In: Lanzer, P. (eds) Catheter-Based Cardiovascular Interventions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27676-7_31

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-27676-7_31

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-27675-0

  • Online ISBN: 978-3-642-27676-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics