Hyaluronan Inside and Outside of Skin

  • Aziza Wahby
  • Kathleen Daddario DiCaprio
  • Robert Stern


Hyaluronan is a major component of the extracellular matrix of skin and is important in the metabolism of both epidermis and dermis. Hyaluronan is responsible for hydration, nutrient exchange, and protects against free radical damage via a multitude of signaling pathways. It is also involved in basic biologic processes such as cell differentiation and motility. An overview is provided here that provides recent information, bringing up-to-date advances in hyaluronan and matrix biology relevant for dermatology and skin care, with a particular emphasis on skin moisture. The differences between hyaluronan applied exogenously and that occurring naturally in the body are articulated.


Dermal Fibroblast Lamellar Body Alopecia Areata Free Radical Damage Variant Exon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Aziza Wahby
    • 1
  • Kathleen Daddario DiCaprio
    • 1
  • Robert Stern
    • 1
  1. 1.Department of Basic Medical SciencesTouro College of Osteopathic MedicineNew YorkUSA

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