Impact of Stratum Corneum Damage on Natural Moisturizing Factor (NMF) in the Skin

  • Lisa M. Kroll
  • Douglas R. Hoffman
  • Corey Cunningham
  • David W. Koenig
Chapter

Abstract

The stratum corneum (SC) is a complex structure that protects our bodies and makes it possible for mammalian life on this planet. The SC employs a combination of both physical and biochemical processes to limit the movement of water in and out of the body although clearly it is the latter that is of most importance. The SC can be disturbed by comparatively minor injury caused by mechanical, occlusive, enzymatic, and chemical damages. Lipids and a family of hygroscopic molecules known as natural moisturizing factor (NMF) are vital to the SC’s ability to regulate epidermal permeability. This chapter reviews what is known about the impact of barrier disruption on key skin components and provides new insights into NMF responses following damage induced by sodium lauryl sulfate (SLS).

Keywords

Stratum Corneum Sodium Lauryl Sulfate Lamellar Body Arginase Activity Barrier Disruption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Lisa M. Kroll
    • 1
  • Douglas R. Hoffman
    • 1
  • Corey Cunningham
    • 1
  • David W. Koenig
    • 1
  1. 1.Corporate Research & EngineeringKimberly-Clark CorporationNeenahUSA

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