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Update on Infant Skin with Special Focus on Dryness and the Impact of Moisturizers

  • Georgios N. Stamatas
  • Neena K. Tierney
Chapter

Abstract

Throughout infancy, skin differs from that of an adult in structure, function, and composition and has water-handling properties that are markedly distinct. Although competent to prevent dehydration, immature skin barrier function leaves infants especially vulnerable to the environment with potential for development of skin irritations elicited, for example, by contact with allergens or exposure to harsh climatic conditions. To this is added a relatively high risk for the development of the inflammatory disease atopic dermatitis. Specially formulated moisturizers are thus needed that respect the specific properties of infant skin and protect it by enhancing the barrier properties without interfering with the natural development.

Keywords

Atopic Dermatitis Stratum Corneum Barrier Function Lamellar Body Dermal Papilla 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgement

The authors would like to thank Dr. Beate Gerstbrein of Ascopharm for editorial assistance.

References

  1. 1.
    Lippens S, Hoste E, Vandenabeele P, Agostinis P, Declercq W (2009) Cell death in the skin. Apoptosis 14:549–569PubMedCrossRefGoogle Scholar
  2. 2.
    Williams AC (2003) Structure and function of human skin. Transdermal and topical drug delivery. Pharmaceutical Press, LondonGoogle Scholar
  3. 3.
    Elias PM (1991) Epidermal barrier function: intercellular lamellar lipid structures, origin, composition and metabolism. J Control Release 15:199–208CrossRefGoogle Scholar
  4. 4.
    Candi E, Oddi S, Terrinoni A, Paradisi A, Ranalli M et al (2001) Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro. J Biol Chem 276:35014–35023PubMedCrossRefGoogle Scholar
  5. 5.
    Pillai S, Cornell M, Oresajo C (2010) Epidermal barrier. In: Draelos ZD (ed) Cosmetic dermatology. Wiley-Blackwell, Chichester, pp 3–12Google Scholar
  6. 6.
    Wertz PW (2000) Lipids and barrier function of the skin. Acta Derm Venereol Suppl (Stockh) 208:7–11CrossRefGoogle Scholar
  7. 7.
    Suzuki Y, Nomura J, Koyama J, Horii I (1994) The role of proteases in stratum corneum: involvement in stratum corneum desquamation. Arch Dermatol Res 286:249–253PubMedCrossRefGoogle Scholar
  8. 8.
    Akiyama M, Smith LT, Yoneda K, Holbrook KA, Hohl D et al (1999) Periderm cells form cornified cell envelope in their regression process during human epidermal development. J Invest Dermatol 112:903–909PubMedCrossRefGoogle Scholar
  9. 9.
    Evans NJ, Rutter N (1986) Development of the epidermis in the newborn. Biol Neonate 49:74–80PubMedCrossRefGoogle Scholar
  10. 10.
    Nikolovski J, Stamatas GN, Kollias N, Wiegand BC (2008) Barrier function and water-holding and transport properties of infant stratum corneum are different from adult and continue to develop through the first year of life. J Invest Dermatol 128:1728–1736PubMedCrossRefGoogle Scholar
  11. 11.
    Stamatas GN, Nikolovski J, Luedtke MA, Kollias N, Wiegand BC (2010) Infant skin microstructure assessed in vivo differs from adult skin in organization and at the cellular level. Pediatr Dermatol 27:125–131PubMedCrossRefGoogle Scholar
  12. 12.
    Chiou YB, Blume-Peytavi U (2004) Stratum corneum maturation. A review of neonatal skin function. Skin Pharmacol Physiol 17:57–66PubMedCrossRefGoogle Scholar
  13. 13.
    Giusti F, Martella A, Bertoni L, Seidenari S (2001) Skin barrier, hydration, and pH of the skin of infants under 2 years of age. Pediatr Dermatol 18:93–96PubMedCrossRefGoogle Scholar
  14. 14.
    Akdis CA, Akdis M, Bieber T, Bindslev-Jensen C, Boguniewicz M et al (2006) Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report. J Allergy Clin Immunol 118:152–169PubMedCrossRefGoogle Scholar
  15. 15.
    Berg RW, Milligan MC, Sarbaugh FC (1994) Association of skin wetness and pH with diaper dermatitis. Pediatr Dermatol 11:18–20PubMedCrossRefGoogle Scholar
  16. 16.
    Stamatas GN, Zerweck C, Grove G, Martin KM (2011) Documentation of impaired epidermal barrier in mild and moderate diaper dermatitis in vivo using noninvasive methods. Pediatr Dermatol 28:99–107PubMedCrossRefGoogle Scholar
  17. 17.
    Agache P, Blanc D, Barrand C, Laurent R (1980) Sebum levels during the first year of life. Br J Dermatol 103:643–649PubMedCrossRefGoogle Scholar
  18. 18.
    Behrendt H, Green M (1969) Drug-induced localized sweating in full-size and low-birth-weight neonates. Am J Dis Child 117:299–306PubMedGoogle Scholar
  19. 19.
    Stamatas GN, Nikolovski J, Mack MC, Kollias N (2011) Infant skin physiology and development during the first years of life: a review of recent findings based on in vivo studies. Int J Cosmet Sci 33:17–24PubMedCrossRefGoogle Scholar
  20. 20.
    Lee SH, Jeong SK, Ahn SK (2006) An update of the defensive barrier function of skin. Yonsei Med J 47:293–306PubMedCrossRefGoogle Scholar
  21. 21.
    Rawlings AV (2003) Trends in stratum corneum research and the management of dry skin conditions. Int J Cosmet Sci 25:63–95PubMedCrossRefGoogle Scholar
  22. 22.
    Rawlings AV, Scott IR, Harding CR, Bowser PA (1994) Stratum corneum moisturization at the molecular level. J Invest Dermatol 103:731–741PubMedCrossRefGoogle Scholar
  23. 23.
    Machado M, Salgado TM, Hadgraft J, Lane ME (2010) The relationship between transepidermal water loss and skin permeability. Int J Pharm 384:73–77PubMedCrossRefGoogle Scholar
  24. 24.
    Rawlings A, Harding C, Watkinson A, Banks J, Ackerman C et al (1995) The effect of glycerol and humidity on desmosome degradation in stratum corneum. Arch Dermatol Res 287:457–464PubMedCrossRefGoogle Scholar
  25. 25.
    Rawlings AV, Harding CR (2004) Moisturization and skin barrier function. Dermatol Ther 17(Suppl 1):43–48PubMedCrossRefGoogle Scholar
  26. 26.
    Wertz PW (2004) Stratum corneum lipids and water. Exog Dermatol 3:53–56CrossRefGoogle Scholar
  27. 27.
    Scott IR, Harding CR (1986) Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment. Dev Biol 115:84–92PubMedCrossRefGoogle Scholar
  28. 28.
    Bouwstra JA, Groenink HW, Kempenaar JA, Romeijn SG, Ponec M (2008) Water distribution and natural moisturizer factor content in human skin equivalents are regulated by environmental relative humidity. J Invest Dermatol 128:378–388PubMedGoogle Scholar
  29. 29.
    Choi EH, Man MQ, Wang F, Zhang X, Brown BE et al (2005) Is endogenous glycerol a determinant of stratum corneum hydration in humans? J Invest Dermatol 125:288–293PubMedGoogle Scholar
  30. 30.
    Sator PG, Schmidt JB, Honigsmann H (2003) Comparison of epidermal hydration and skin surface lipids in healthy individuals and in patients with atopic dermatitis. J Am Acad Dermatol 48:352–358PubMedCrossRefGoogle Scholar
  31. 31.
    Nakagawa N, Sakai S, Matsumoto M, Yamada K, Nagano M et al (2004) Relationship between NMF (lactate and potassium) content and the physical properties of the stratum corneum in healthy subjects. J Invest Dermatol 122:755–763PubMedCrossRefGoogle Scholar
  32. 32.
    Sato J (2002) Desquamation and the role of stratum corneum enzymes. In: Leyden JJ, Rawlings AV (eds) Skin moisturization. Marcel Dekker Inc, New York, pp 79–92Google Scholar
  33. 33.
    Watkinson A, Harding C, Moore A, Coan P (2001) Water modulation of stratum corneum chymotryptic enzyme activity and desquamation. Arch Dermatol Res 293:470–476PubMedCrossRefGoogle Scholar
  34. 34.
    Sato J, Denda M, Nakanishi J, Nomura J, Koyama J (1998) Cholesterol sulfate inhibits proteases that are involved in desquamation of stratum corneum. J Invest Dermatol 111:189–193PubMedCrossRefGoogle Scholar
  35. 35.
    Deraison C, Bonnart C, Lopez F, Besson C, Robinson R et al (2007) LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction. Mol Biol Cell 18:3607–3619PubMedCrossRefGoogle Scholar
  36. 36.
    Hachem JP, Man MQ, Crumrine D, Uchida Y, Brown BE et al (2005) Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity. J Invest Dermatol 125:510–520PubMedCrossRefGoogle Scholar
  37. 37.
    Hachem JP, Crumrine D, Fluhr J, Brown BE, Feingold KR et al (2003) pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion. J Invest Dermatol 121:345–353PubMedCrossRefGoogle Scholar
  38. 38.
    Choi EH, Man MQ, Xu P, Xin S, Liu Z et al (2007) Stratum corneum acidification is impaired in moderately aged human and murine skin. J Invest Dermatol 127:2847–2856PubMedCrossRefGoogle Scholar
  39. 39.
    Menon GK, Price LF, Bommannan B, Elias PM, Feingold KR (1994) Selective obliteration of the epidermal calcium gradient leads to enhanced lamellar body secretion. J Invest Dermatol 102:789–795PubMedCrossRefGoogle Scholar
  40. 40.
    Hitomi K (2005) Transglutaminases in skin epidermis. Eur J Dermatol 15:313–319PubMedGoogle Scholar
  41. 41.
    Menon GK, Grayson S, Elias PM (1985) Ionic calcium reservoirs in mammalian epidermis: ultrastructural localization by ion-capture cytochemistry. J Invest Dermatol 84:508–512PubMedCrossRefGoogle Scholar
  42. 42.
    Elias P, Ahn S, Brown B, Crumrine D, Feingold KR (2002) Origin of the epidermal calcium gradient: regulation by barrier status and role of active vs passive mechanisms. J Invest Dermatol 119:1269–1274PubMedCrossRefGoogle Scholar
  43. 43.
    Chu M, Kollias N (2011) Documentation of normal stratum corneum scaling in an average population: features of differences among age, ethnicity and body site. Br J Dermatol 164:497–507PubMedGoogle Scholar
  44. 44.
    Schatz H, Altmeyer PJ, Kligman AM (1995) Dry skin and scaling evaluated by D-squames and image analysis. In: Serup J, Jemec GBE (eds) Handbook of non-invasive methods and the skin. CRC Press, Boca Raton, pp 377–384Google Scholar
  45. 45.
    Corcuff P (2004) In vivo confocal microscopy. In: Agache P, Humbert P (eds) Measuring the skin. Springer, Berlin/Heidelberg/New York, pp 183–193Google Scholar
  46. 46.
    Berardesca E (1997) EEMCO guidance for the assessment of stratum corneum hydration: electrical methods. Skin Res Technol 3:126–132CrossRefGoogle Scholar
  47. 47.
    Blichmann CW, Serup J (1988) Assessment of skin moisture. Measurement of electrical conductance, capacitance and transepidermal water loss. Acta Derm Venereol 68:284–290PubMedGoogle Scholar
  48. 48.
    Caspers PJ, Lucassen GW, Bruining HA, Puppels GJ (2000) Automated depth-scanning confocal Raman microspectrometer for rapid in vivo determination of water concentration profiles in human skin. J Raman Spectrosc 31:813–818CrossRefGoogle Scholar
  49. 49.
    Caspers PJ, Lucassen GW, Carter EA, Bruining HA, Puppels GJ (2001) In vivo confocal Raman microspectroscopy of the skin: noninvasive determination of molecular concentration profiles. J Invest Dermatol 116:434–442PubMedCrossRefGoogle Scholar
  50. 50.
    Brancaleon L, Bamberg MP, Sakamaki T, Kollias N (2001) Attenuated total reflection-Fourier transform infrared spectroscopy as a possible method to investigate biophysical parameters of stratum corneum in vivo. J Invest Dermatol 116:380–386PubMedCrossRefGoogle Scholar
  51. 51.
    Levin J, Maibach H (2005) The correlation between transepidermal water loss and percutaneous absorption: an overview. J Control Release 103:291–299PubMedCrossRefGoogle Scholar
  52. 52.
    Distante F, Berardesca E (1995) Transepidermal water loss. In: Berardesca E, Elsner P, Wilhelm K-P, Maibach HI (eds) Bioengineering of the skin: methods and instrumentation. CRC Press, Boca Raton/New York/London/Tokyo, pp 1–4Google Scholar
  53. 53.
    Imhof RE, De Jesus ME, Xiao P, Ciortea LI, Berg EP (2009) Closed-chamber transepidermal water loss measurement: microclimate, calibration and performance. Int J Cosmet Sci 31:97–118PubMedCrossRefGoogle Scholar
  54. 54.
    Pinnagoda J, Tupker RA (1995) Measurement of the transepidermal water loss. In: Serup J, Jemec BE (eds) Handbook of non-invasive methods and the skin. CRC Press, Boca Raton/Ann Arbor/London/Tokyo, pp 173–178Google Scholar
  55. 55.
    Tagami H, Kanamaru Y, Inoue K, Suehisa S, Inoue F et al (1982) Water sorption–desorption test of the skin in vivo for functional assessment of the stratum corneum. J Invest Dermatol 78:425–428PubMedCrossRefGoogle Scholar
  56. 56.
    Hoath SB, Pickens WL, Visscher MO (2006) The biology of vernix caseosa. Int J Cosmet Sci 28:319–333PubMedCrossRefGoogle Scholar
  57. 57.
    Vitellaro-Zuccarello L, Cappelletti S, Dal Pozzo Rossi V, Sari-Gorla M (1994) Stereological analysis of collagen and elastic fibers in the normal human dermis: variability with age, sex, and body region. Anat Rec 238:153–162PubMedCrossRefGoogle Scholar
  58. 58.
    Hoeger PH, Enzmann CC (2002) Skin physiology of the neonate and young infant: a prospective study of functional skin parameters during early infancy. Pediatr Dermatol 19:256–262PubMedCrossRefGoogle Scholar
  59. 59.
    Saijo S, Tagami H (1991) Dry skin of newborn infants: functional analysis of the stratum corneum. Pediatr Dermatol 8:155–159PubMedCrossRefGoogle Scholar
  60. 60.
    Yosipovitch G, Maayan-Metzger A, Merlob P, Sirota L (2000) Skin barrier properties in different body areas in neonates. Pediatrics 106:105–108PubMedCrossRefGoogle Scholar
  61. 61.
    Visscher MO, Chatterjee R, Munson KA, Pickens WL, Hoath SB (2000) Changes in diapered and nondiapered infant skin over the first month of life. Pediatr Dermatol 17:45–51PubMedCrossRefGoogle Scholar
  62. 62.
    Mack MC, Tierney NK, Ruvolo E Jr, Stamatas GN, Martin KM et al (2010) Development of solar UVR-related pigmentation begins as early as the first summer of life. J Invest Dermatol 130:2335–2338PubMedCrossRefGoogle Scholar
  63. 63.
    Gallagher RP, Hill GB, Bajdik CD, Fincham S, Coldman AJ et al (1995) Sunlight exposure, pigmentary factors, and risk of nonmelanocytic skin cancer. I. Basal cell carcinoma. Arch Dermatol 131:157–163PubMedCrossRefGoogle Scholar
  64. 64.
    Mills O, Messina JL (2009) Pediatric melanoma: a review. Cancer Control 16:225–233PubMedGoogle Scholar
  65. 65.
    Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G et al (2010) Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A 107:11971–11975PubMedCrossRefGoogle Scholar
  66. 66.
    Capone K, Dowd SE, Stamatas GN, Nikolovski J (2010) Survey of bacterial diversity on infant skin over the first year of life (abstract 744). J Invest Dermatol 130(S1):S124Google Scholar
  67. 67.
    Costello EK, Lauber CL, Hamady M, Fierer N, Gordon JI et al (2009) Bacterial community variation in human body habitats across space and time. Science 326:1694–1697PubMedCrossRefGoogle Scholar
  68. 68.
    Gao Z, Tseng CH, Pei Z, Blaser MJ (2007) Molecular analysis of human forearm superficial skin bacterial biota. Proc Natl Acad Sci U S A 104:2927–2932PubMedCrossRefGoogle Scholar
  69. 69.
    Grice EA, Kong HH, Conlan S, Deming CB, Davis J et al (2009) Topographical and temporal diversity of the human skin microbiome. Science 324:1190–1192PubMedCrossRefGoogle Scholar
  70. 70.
    Grice EA, Kong HH, Renaud G, Young AC, Bouffard GG et al (2008) A diversity profile of the human skin microbiota. Genome Res 18:1043–1050PubMedCrossRefGoogle Scholar
  71. 71.
    Wanke I, Steffen H, Christ C, Krismer B, Gotz F et al (2011) Skin commensals amplify the innate immune response to pathogens by activation of distinct signaling pathways. J Invest Dermatol 131:382–390PubMedCrossRefGoogle Scholar
  72. 72.
    Elias PM (1983) Epidermal lipids, barrier function, and desquamation. J Invest Dermatol 80(Suppl):44s–49sCrossRefGoogle Scholar
  73. 73.
    Braun-Falco O, Korting HC (1986) Normal pH value of human skin. Hautarzt 37:126–129PubMedGoogle Scholar
  74. 74.
    Fluhr JW, Pfisterer S, Gloor M (2000) Direct comparison of skin physiology in children and adults with bioengineering methods. Pediatr Dermatol 17:436–439PubMedCrossRefGoogle Scholar
  75. 75.
    Matousek JL, Campbell KL (2002) A comparative review of cutaneous pH. Vet Dermatol 13:293–300PubMedCrossRefGoogle Scholar
  76. 76.
    Korting HC, Hubner K, Greiner K, Hamm G, Braun-Falco O (1990) Differences in the skin surface pH and bacterial microflora due to the long-term application of synthetic detergent preparations of pH 5.5 and pH 7.0. Results of a crossover trial in healthy volunteers. Acta Derm Venereol 70:429–431PubMedGoogle Scholar
  77. 77.
    Mauro T, Holleran WM, Grayson S, Gao WN, Man MQ et al (1998) Barrier recovery is impeded at neutral pH, independent of ionic effects: implications for extracellular lipid processing. Arch Dermatol Res 290:215–222PubMedCrossRefGoogle Scholar
  78. 78.
    Henderson CA, Taylor J, Cunliffe WJ (2000) Sebum excretion rates in mothers and neonates. Br J Dermatol 142:110–111PubMedCrossRefGoogle Scholar
  79. 79.
    Harpin VA, Rutter N (1982) Development of emotional sweating in the newborn infant. Arch Dis Child 57:691–695PubMedCrossRefGoogle Scholar
  80. 80.
    Rutter N (2003) Eccrine sweating in the newborn. In: Hoath SB, Maibach HI (eds) Neonatal skin structure and function. Marcel Dekker, New YorkGoogle Scholar
  81. 81.
    Brenner M, Hearing VJ (2008) The protective role of melanin against UV damage in human skin. Photochem Photobiol 84:539–549PubMedCrossRefGoogle Scholar
  82. 82.
    Berneburg M, Surber C (2009) Children and sun protection. Br J Dermatol 161(Suppl 3):33–39PubMedCrossRefGoogle Scholar
  83. 83.
    Chu M, Tierney N, Ruvolo E, Stamatas GN, Kollias N et al (2010) Infant skin is similar in New Jersey and Mumbai and markedly different in Beijing in winter (abstract 253). J Invest Dermatol 130(S1):S43Google Scholar
  84. 84.
    Rogers J, Harding C, Mayo A, Banks J, Rawlings A (1996) Stratum corneum lipids: the effect of ageing and the seasons. Arch Dermatol Res 288:765–770PubMedCrossRefGoogle Scholar
  85. 85.
    Hirao T, Aoki H, Yoshida T, Sato Y, Kamoda H (1996) Elevation of interleukin 1 receptor antagonist in the stratum corneum of sun-exposed and ultraviolet B-irradiated human skin. J Invest Dermatol 106:1102–1107PubMedCrossRefGoogle Scholar
  86. 86.
    Terui T, Hirao T, Sato Y, Uesugi T, Honda M et al (1998) An increased ratio of interleukin-1 receptor antagonist to interleukin-1alpha in inflammatory skin diseases. Exp Dermatol 7:327–334PubMedCrossRefGoogle Scholar
  87. 87.
    Perkins MA, Osterhues MA, Farage MA, Robinson MK (2001) A noninvasive method to assess skin irritation and compromised skin conditions using simple tape adsorption of molecular markers of inflammation. Skin Res Technol 7:227–237PubMedCrossRefGoogle Scholar
  88. 88.
    Tierney NK, Kothari PD, Martin KM (2010) Investigation into skin reactivity as a function of age: a focus on children less than 2 years of age. International Pediatric Association 26th International Congress of Pediatrics. Johannesburg, South AfricaGoogle Scholar
  89. 89.
    Adalat S, Wall D, Goodyear H (2007) Diaper dermatitis-frequency and contributory factors in hospital attending children. Pediatr Dermatol 24:483–488PubMedCrossRefGoogle Scholar
  90. 90.
    Jordan WE, Lawson KD, Berg RW, Franxman JJ, Marrer AM (1986) Diaper dermatitis: frequency and severity among a general infant population. Pediatr Dermatol 3:198–207PubMedCrossRefGoogle Scholar
  91. 91.
    Visscher MO, Chatterjee R, Munson KA, Bare DE, Hoath SB (2000) Development of diaper rash in the newborn. Pediatr Dermatol 17:52–57PubMedCrossRefGoogle Scholar
  92. 92.
    Atherton DJ (2001) The aetiology and management of irritant diaper dermatitis. J Eur Acad Dermatol Venereol 15(Suppl 1):1–4PubMedCrossRefGoogle Scholar
  93. 93.
    Buckingham KW, Berg RW (1986) Etiologic factors in diaper dermatitis: the role of feces. Pediatr Dermatol 3:107–112PubMedCrossRefGoogle Scholar
  94. 94.
    Berg RW, Buckingham KW, Stewart RL (1986) Etiologic factors in diaper dermatitis: the role of urine. Pediatr Dermatol 3:102–106PubMedCrossRefGoogle Scholar
  95. 95.
    Benjamin L (1987) Clinical correlates with diaper dermatitis. Pediatrician 14(Suppl 1):21–26PubMedGoogle Scholar
  96. 96.
    Atherton D, Mills K (2004) What can be done to keep babies’ skin healthy? RCM Midwives 7:288–290PubMedGoogle Scholar
  97. 97.
    Blume-Peytavi U, Cork MJ, Faergemann J, Szczapa J, Vanaclocha F et al (2009) Bathing and cleansing in newborns from day 1 to first year of life: recommendations from a European round table meeting. J Eur Acad Dermatol Venereol 23:751–759PubMedCrossRefGoogle Scholar
  98. 98.
    Gupta AK, Skinner AR (2004) Management of diaper dermatitis. Int J Dermatol 43:830–834PubMedCrossRefGoogle Scholar
  99. 99.
    Laughter D, Istvan JA, Tofte SJ, Hanifin JM (2000) The prevalence of atopic dermatitis in Oregon schoolchildren. J Am Acad Dermatol 43:649–655PubMedCrossRefGoogle Scholar
  100. 100.
    Schultz Larsen F, Diepgen T, Svensson A (1996) The occurrence of atopic dermatitis in north Europe: an international questionnaire study. J Am Acad Dermatol 34:760–764PubMedCrossRefGoogle Scholar
  101. 101.
    Kay J, Gawkrodger DJ, Mortimer MJ, Jaron AG (1994) The prevalence of childhood atopic eczema in a general population. J Am Acad Dermatol 30:35–39PubMedCrossRefGoogle Scholar
  102. 102.
    Cork MJ, Danby SG, Vasilopoulos Y, Hadgraft J, Lane ME et al (2009) Epidermal barrier dysfunction in atopic dermatitis. J Invest Dermatol 129:1892–1908PubMedCrossRefGoogle Scholar
  103. 103.
    Spergel JM, Paller AS (2003) Atopic dermatitis and the atopic march. J Allergy Clin Immunol 112:S118–S127PubMedCrossRefGoogle Scholar
  104. 104.
    Gustafsson D, Sjoberg O, Foucard T (2000) Development of allergies and asthma in infants and young children with atopic dermatitis – a prospective follow-up to 7 years of age. Allergy 55:240–245PubMedCrossRefGoogle Scholar
  105. 105.
    Eichenfield LF, Hanifin JM, Beck LA, Lemanske RF Jr, Sampson HA et al (2003) Atopic dermatitis and asthma: parallels in the evolution of treatment. Pediatrics 111:608–616PubMedCrossRefGoogle Scholar
  106. 106.
    Seidenari S, Giusti G (1995) Objective assessment of the skin of children affected by atopic dermatitis: a study of pH, capacitance and TEWL in eczematous and clinically uninvolved skin. Acta Derm Venereol 75:429–433PubMedGoogle Scholar
  107. 107.
    Krakowski AC, Eichenfield LF, Dohil MA (2008) Management of atopic dermatitis in the pediatric population. Pediatrics 122:812–824PubMedCrossRefGoogle Scholar
  108. 108.
    Beck LA, Leung DY (2000) Allergen sensitization through the skin induces systemic allergic responses. J Allergy Clin Immunol 106:S258–S263PubMedCrossRefGoogle Scholar
  109. 109.
    Arshad SH, Bateman B, Sadeghnejad A, Gant C, Matthews SM (2007) Prevention of allergic disease during childhood by allergen avoidance: the Isle of Wight prevention study. J Allergy Clin Immunol 119:307–313PubMedCrossRefGoogle Scholar
  110. 110.
    Loden M (2003) Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol 4:771–788PubMedCrossRefGoogle Scholar
  111. 111.
    Stamatas GN, de Sterke J, Hauser M, von Stetten O, van der Pol A (2008) Lipid uptake and skin occlusion following topical application of oils on adult and infant skin. J Dermatol Sci 50:135–142PubMedCrossRefGoogle Scholar
  112. 112.
    Harding CR, Watkinson A, Rawlings AV, Scott IR (2000) Dry skin, moisturization and corneodesmolysis. Int J Cosmet Sci 22:21–52PubMedCrossRefGoogle Scholar
  113. 113.
    Lund CH, Kuller J, Raines DA, Ecklund S, Archambault ME et al (2007) Neonatal skin care – evidence-based clinical practice guideline. Association of Women’s Health, Obstetric and Neonatal Nurses and the National Association of Neonatal Nurses, WashingtonGoogle Scholar
  114. 114.
    Garcia Bartels N, Mleczko A, Schink T, Proquitte H, Wauer RR et al (2009) Influence of bathing or washing on skin barrier function in newborns during the first four weeks of life. Skin Pharmacol Physiol 22:248–257PubMedCrossRefGoogle Scholar
  115. 115.
    Bryanton J, Walsh D, Barrett M, Gaudet D (2004) Tub bathing versus traditional sponge bathing for the newborn. J Obstet Gynecol Neonatal Nurs 33:704–712PubMedCrossRefGoogle Scholar
  116. 116.
    Henningsson A, Nystrom B, Tunnell R (1981) Bathing or washing babies after birth? Lancet 2:1401–1403PubMedCrossRefGoogle Scholar
  117. 117.
    Eichenfield LF, Hanifin JM, Luger TA, Stevens SR, Pride HB (2003) Consensus conference on pediatric atopic dermatitis. J Am Acad Dermatol 49:1088–1095PubMedCrossRefGoogle Scholar
  118. 118.
    Garcia Bartels N, Scheufele R, Prosch F, Schink T, Proquitte H et al (2010) Effect of standardized skin care regimens on neonatal skin barrier function in different body areas. Pediatr Dermatol 27:1–8PubMedCrossRefGoogle Scholar
  119. 119.
    Telofski LS, Niciporciukas C, Kurtz ES (2007) Regimen of a moisturizing cleanser and gentle moisturizer provides soothing relief of dry skin and extra-dry patches for infants. International Pediatric Association 25th International Congress of Pediatrics. Athens, GreeceGoogle Scholar
  120. 120.
    Telofski LS, Niciporciukas C, Kurtz ES (2007) Evaluation of tolerance and efficacy of an infant facial balm on mild to moderate dry/chapped facial skin. International Pediatric Association 25th International Congress of Pediatrics. Athens, GreeceGoogle Scholar
  121. 121.
    Warner RR, Stone KJ, Boissy YL (2003) Hydration disrupts human stratum corneum ultrastructure. J Invest Dermatol 120:275–284PubMedCrossRefGoogle Scholar
  122. 122.
    Warren R, Ertel KD, Bartolo RG, Levine MJ, Bryant PB et al (1996) The influence of hard water (calcium) and surfactants on irritant contact dermatitis. Contact Dermatitis 35:337–343PubMedCrossRefGoogle Scholar
  123. 123.
    McNally NJ, Williams HC, Phillips DR, Smallman-Raynor M, Lewis S et al (1998) Atopic eczema and domestic water hardness. Lancet 352:527–531PubMedCrossRefGoogle Scholar
  124. 124.
    Loden M, Buraczewska I, Edlund F (2004) Irritation potential of bath and shower oils before and after use: a double-blind randomized study. Br J Dermatol 150:1142–1147PubMedCrossRefGoogle Scholar
  125. 125.
    Buraczewska I, Berne B, Lindberg M, Torma H, Loden M (2007) Changes in skin barrier function following long-term treatment with moisturizers, a randomized controlled trial. Br J Dermatol 156:492–498PubMedCrossRefGoogle Scholar
  126. 126.
    Visscher MO, Chatterjee R, Ebel JP, LaRuffa AA, Hoath SB (2002) Biomedical assessment and instrumental evaluation of healthy infant skin. Pediatr Dermatol 19:473–481PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Research and DevelopmentJohnson & Johnson Santé Beauté FranceIssy-les-MoulineauxFrance
  2. 2.Research and DevelopmentJohnson & Johnson Consumer Companies IncSkillmanUSA

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