The Role of Tight Junctions and Aquaporins in Skin Dryness

Chapter

Abstract

The maintenance of optimum water content in the skin and especially in the epidermis is provided by many orchestrated mechanisms. Water uptake into the dermis/epidermis, paracellular and transcellular water transport through the epidermis and water retention as well as controlled water loss in the stratum corneum have to be coordinated. Unbalance of these mechanisms results in dry skin. Following its paracellular route, water has to pass tight junctions before it can get into contact with the stratum corneum. For the transcellular route water channels, formed by so-called aquaporins, are of importance. Here, I will summarize our current knowledge of the involvement of aquaporin-formed pores and tight junctions in epidermal water homeostasis – as well as in other functions – and their putative roles in skin dryness.

Keywords

Atopic Dermatitis Stratum Corneum HaCaT Cell Merkel Cell Carcinoma AQP3 Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Dermatology and VenerologyUniversity-Hospital Hamburg-EppendorfHamburgGermany

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