Abstract
The aim of our study was to assess the association of PS1 gene polymorphisms with Alzheimer’s disease in Chinese population using a meta-analysis. We identified 11 studies and found significant associations with Alzheimer’s disease for 1/2 genotype of PS1 gene polymorphism (odds ratio 0.69, 95%confidence interval 0.50–0.94, P=0.02), under dominant and recessive genetic models, associations were also exited. The heterogeneity existed among all studies (P<0.05).The present meta-analysis suggested a significant association of PS1 gene polymorphisms with Alzheimer’s disease in Chinese population. The 1/2 genotype of PS1 gene is associated with risk for Alzheimer’s disease in the Chinese population.
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Zhang, Y., Xu, Y., Nei, H. (2012). Association of PS1 Gene Polymorphisms with Alzheimer’s Disease in Chinese Population: A Meta-Analysis of Case-Control Studies. In: Zhu, E., Sambath, S. (eds) Information Technology and Agricultural Engineering. Advances in Intelligent and Soft Computing, vol 134. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27537-1_21
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DOI: https://doi.org/10.1007/978-3-642-27537-1_21
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