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Optical Coherence Tomography Updates on Clinical and Technical Developments. Age-Related Macular Degeneration: Drusen and Geographic Atrophy

  • Monika Fleckenstein
  • Steffen Schmitz-Valckenberg
  • Frank G. Holz
Chapter
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Abstract

Age-related macular degeneration (AMD) is a complex disease with both genetic and environmental factors influencing its development. With the advent of high-resolution OCT imaging, the characterization of drusen in AMD has become possible. The in vivo morphologic characteristics imaged with SD-OCT may represent distinct subclasses of drusen variants, may relate closely to ultrastructural drusen elements identified in donor eyes, and may be useful imaging biomarkers for disease severity or risk of progression [Khanifar et al. Ophthalmology 115(11):1883–1890, 2008].

Keywords

Retinal Pigment Epithelium Retinal Pigment Epithelium Cell Retinal Thickness External Limit Membrane Outer Retinal Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Monika Fleckenstein
    • 1
  • Steffen Schmitz-Valckenberg
    • 1
  • Frank G. Holz
    • 2
  1. 1.Department of OphthalmologyUniversity of BonnBonnGermany
  2. 2.Department of OphthalmologyUniversity of BonnBonnGermany

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