Innate Immune Responses to Hepatitis C Virus

  • John W. Schoggins
  • Charles M. Rice
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 369)


The innate immune response provides the first line of defense against invading viral pathogens. Incoming viruses are sensed by dedicated host factors that, when triggered, initiate multiple signal transduction pathways. Activation of these pathways leads to the induction of highly orchestrated transcriptional programs designed to limit virus replication and spread. In recent years, our understanding of innate immune responses targeting hepatitis C virus (HCV) has increased substantially, largely due to the development of new systems and methodologies to study HCV–host interactions in vitro and in vivo. However, significant gaps still remain. Here, we aim to provide a comprehensive view of the innate immune response to HCV, focusing primarily on knowledge gained from cell culture models of HCV infection, as well as data from human patients infected with HCV. While some paradigms of the host response to HCV revealed in cell culture translate to human infection in vivo, others are less clear. Further insight into the similarities and differences in these systems will not only reveal directions for future studies on HCV immunity, but may also guide the development of novel strategies to control HCV and other viral infections.


Huh7 Cell IL28B Genotype Antiviral Signaling IL28B mRNA Level Primary Human Hepatocyte Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of MicrobiologyUniversity of Texas Southwestern Medical CenterDallasUSA
  2. 2.Laboratory of Virology and Infectious DiseaseCenter for the Study of Hepatitis C, The Rockefeller UniversityNew YorkUSA

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