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Hepatitis C Virus-Specific Directly Acting Antiviral Drugs

  • Chapter
Hepatitis C Virus: From Molecular Virology to Antiviral Therapy

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 369))

Abstract

The major targets for direct-acting antivirals (DAAs) are the NS3/4A protease, the NS5A protein, and the NS5B polymerase. The latter enzyme offers several target sites: the catalytic domain for nucleoside/nucleotide analogs and different allosteric sites for non-nucleoside inhibitors. Two protease inhibitors have already been approved and more than 40 new NS3/4A, NS5A, or NS5B inhibitors are in development pipeline. Not only these agents can achieve very high cure rates when combined with PEG-IFN and RBV, but have also started to provide promising results when combined in IFN-free, all-oral combinations. In addition to the more canonical drug targets, new alternative viral targets for small molecule drug development are emerging, such as p7 or NS4B. Current research is focusing on defining the most efficacious DAA combination regimens, i.e., those which provide the highest rates of viral eradication, broadest spectrum of action, minimal or no clinical resistance, shortest treatment duration, and good tolerability.

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  1. Rega Institute for Medical Research, KU Leuven, 3000, Leuven, Belgium

    Leen Delang, Johan Neyts & Inge Vliegen

  2. Istituto Nazionale Genetica Molecolare (INGM), via Francesco Sforza 35, 20122, Milan, Italy

    Sergio Abrignani, Petra Neddermann & Raffaele De Francesco

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  1. Leen Delang
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  2. Johan Neyts
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  6. Raffaele De Francesco
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Correspondence to Raffaele De Francesco .

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  1. Department for Infectious Diseases Molecular Virology, University of Heidelberg, Heidelberg, Germany

    Ralf Bartenschlager

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Delang, L., Neyts, J., Vliegen, I., Abrignani, S., Neddermann, P., De Francesco, R. (2013). Hepatitis C Virus-Specific Directly Acting Antiviral Drugs. In: Bartenschlager, R. (eds) Hepatitis C Virus: From Molecular Virology to Antiviral Therapy. Current Topics in Microbiology and Immunology, vol 369. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27340-7_12

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