Abstract
The range of differential diagnoses for osteolytic lesions in the skeletal system is wide, extending from asymptomatic benign lesions—often diagnosed as incidental findings—to clinically symptomatic high-grade osteosarcomas. In the majority of cases, the lesions are benign and in most cases do not require any therapeutic intervention. Malignant primary bone tumours are a rarity. Due to their inexperience with benign findings, the physicians who initially see the patients (general practitioners, pediatricians, radiologists, orthopaedists, etc.) therefore face a dilemma: on the one hand, they need to carry out extensive diagnostic procedures (including radiological and sometimes also invasive methods) in order to avoid overlooking a possible osteosarcoma. On the other hand, it is by no means rare for patients with an osteosarcoma to be referred to a specialized tumour center only when the lesion is at an extremely advanced stage, as the physicians previously treating the patient did not expect a malignant process.
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Hogendoorn PC, ESMO/EUROBONET Working Group, Athanasou N, Bielack S, De Alava E, Dei Tos AP, Ferrari S, Gelderblom H, Grimer R, Hall KS, Hassan B, Hogendoorn PC, Jurgens H, Paulussen M, Rozeman L, Taminiau AH, Whelan J, Vanel D (2010) Bone sarcomas: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 21(Suppl 5):v204–v213
Jawad MU, Cheung MC, Min ES, Schneiderbauer MM, Koniaris LG, Scully SP (2009) Ewing sarcoma demonstrates racial disparities in incidence-related and sex-related differences in outcome: an analysis of 1631 cases from the SEER database, 1973–2005. Cancer 115:3526–3536
Ottaviani G, Jaffe N (2009) The epidemiology of osteosarcoma. Cancer Treat Res 152:3–13
Giuffrida AY, Burgueno JE, Koniaris LG, Gutierrez JC, Duncan R, Scully SP (2009) Chondrosarcoma in the United States (1973 to 2003): an analysis of 2890 cases from the SEER database. J Bone Joint Surg Am 91:1063–1072
Freyschmidt J, Ostertag H, Jundt G (2003) Knochentumoren – klinik, radiologie, pathologie, 2nd edn. Springer, Berlin
Dirksen U, Jürgerns H (2009) Ewing-Sarkome und PNET des Kindes- und Jugendalters. Leitlinie der Gesellschaft für Pädiatrische Onkologie und Hämatologie. Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften online, Register Nr. 025–006
Leithner A, Windhager R (2007) Guidelines for the biopsy of bone and soft tissue tumors. Orthopade 36:167–174
Walden MJ, Murphey MD, Vidal JA (2008) Incidental enchondromas of the knee. AJR Am J Roentgenol 190:1611–1615
Pan KL, Chan WH, Chia YY (2010) Initial symptoms and delayed diagnosis of osteosarcoma around the knee joint. J Orthop Surg (Hong Kong) 18:55–57
Widhe B, Widhe T (2000) Initial symptoms and clinical features in osteosarcoma and Ewing sarcoma. J Bone Joint Surg Am 82:667–674
Schultheiss M, von Baer A, Gebhard F, Kinzl L, Arand M (2007) Therapy indications and options for skeletal metastasis. Urologe A 46:897–903
Bacci G, Ferrari S, Longhi A, Donati D, Manfrini M, Giacomini S, Briccoli A, Forni C, Galletti S (2003) Nonmetastatic osteosarcoma of the extremity with pathologic fracture at presentation: local and systemic control by amputation or limb salvage after preoperative chemotherapy. Acta Orthop Scand 74:449–454
Lee J, Hoang BH, Ziogas A, Zell JA (2010) Analysis of prognostic factors in Ewing sarcoma using a population-based cancer registry. Cancer 116:1964–1973
Lodwick GS, Wilson AJ, Farrell C, Virtama P, Dittrich F (1980) Determining growth rates of focal lesions of bone from radiographs. Radiology 134:577–583
Bielack S (2010) Osteosarkome. Leitlinie der Gesellschaft für Pädiatrische Onkologie und Hämatologie. Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften online, Register Nr. 025–005
Jacofsky DJ, Haidukewych GJ (2004) Management of pathologic fractures of the proximal femur. State of the art. J Orthop Trauma 18:459–469
Andreou D, Bielack SS, Carrle D, Kevric M, Kotz R, Winkelmann W, Jundt G, Werner M, Fehlberg S, Kager L, Kühne T, Lang S, Dominkus M, Exner GU, Hardes J, Hillmann A, Ewerbeck V, Heise U, Reichardt P, Tunn PU (2011) The influence of tumor- and treatment-related factors on the development of local recurrence in osteosarcoma after adequate surgery. An analysis of 1355 patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols. Ann Oncol 22:1228–1235
Enneking WF, Spanier SS, Goodman MA (1980) A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop Relat Res 153:106–120
Ferguson PC, McLaughlin CE, Griffin AM, Bell RS, Deheshi BM, Wunder JS (2010) Clinical and functional outcomes of patients with a pathologic fracture in high-grade osteosarcoma. J Surg Oncol 102:120–124
Peeters SP, Van der Geest IC, de Rooy JW, Veth RP, Schreuder HW (2009) Aneurysmal bone cyst: the role of cryosurgery as local adjuvant treatment. J Surg Oncol 100:719–724
Pietschmann MF, Dietz RA, Utzschneider S, Baur-Melnyk A, Jansson V, Dürr HR (2010) The influence of adjuvants on local recurrence rate in giant cell tumour of the bone. Acta Chir Belg 110:584–589
Balke M, Schremper L, Gebert C, Ahrens H, Streitbuerger A, Koehler G, Hardes J, Gosheger G (2008) Giant cell tumor of bone: treatment and outcome of 214 cases. J Cancer Res Clin Oncol 134:969–978
Lindfors NC, Koski I, Heikkilä JT, Mattila K, Aho AJ (2010) A prospective randomized 14-year follow-up study of bioactive glass and autogenous bone as bone graft substitutes in benign bone tumors. J Biomed Mater Res B Appl Biomater 94:157–164
Streitbürger A, Ahrens H, Balke M, Buerger H, Winkelmann W, Gosheger G, Hardes J (2009) Grade I chondrosarcoma of bone: the Münster experience. J Cancer Res Clin Oncol 135:543–550
Sluga M, Windhager R, Lang S, Heinzl H, Bielack S, Kotz R (1999) Local and systemic control after ablative and limb sparing surgery in patients with osteosarcoma. Clin Orthop Relat Res 358:120–127
Gosheger G, Gebert C, Ahrens H, Streitbuerger A, Winkelmann W, Hardes J (2006) Endoprosthetic reconstruction in 250 patients with sarcoma. Clin Orthop 450:164–171
Renard AJ, Veth RP, Schreuder HW, van Loon CJ, Koops HS, van Horn JR (2000) Function and complications after ablative and limb-salvage therapy in lower extremity sarcoma of bone. J Surg Oncol 73:198–205
Gebert C, Hillmann A, Schwappach A, Hoffmann C, Hardes J, Kleinheinz J, Gosheger G (2006) Free vascularized fibular grafting for reconstruction after tumour resection in the upper extremity. J Surg Oncol 94:114–127
Henderson ER, Groundland JS, Pala E, Dennis JA, Wooten R, Cheong D, Windhager R, Kotz RI, Mercuri M, Funovics PT, Hornicek FJ, Temple HT, Ruggieri P, Letson GD (2011) Failure mode classification for tumor endoprostheses: retrospective review of five institutions and a literature review. J Bone Joint Surg Am 93:418–429
Krepler P, Dominkus M, Toma CD, Kotz R (2003) Endoprosthesis management of the extremities of children after resection of primary malignant bone tumors. Orthopade 32:1013–1019
Hardes J, Gebert C, Hillmann A, Winkelmann W, Gosheger G (2003) Rotationplasty in the surgical treatment plan of primary malignant bone tumors. Possibilities and limits. Orthopade 32:965–970
Capanna R, De Biase P, Campanacci DA (2003) A new protocol of surgical treatment of long bone metastases. Ortop Traumatol Rehabil 5:271–275
Nathan SS, Healy JH, Mellano D, Hoang B, Lewis I, Morris CD, Athanasian EA, Boland PJ (2005) Survival in patients operated on for pathologic fracture: implications for end-of-life orthopedic care. J Clin Oncol 23:6072–6082
Hardes J, Gosheger G (2008) Die Pathologische Fraktur aus Sicht des Orthopäden/Unfallchirurgen. Trauma und Berufskrankheit 10(Suppl 2):167–174
Cichon CW, Böttner F, Rödl R, Winkelmann W, Lindner N (2006) Minimally invasive treatment of osteoid osteoma with CT-guided radiofrequency ablation in long-term follow-up. Z Orthop Ihre Grenzgeb 144:332–337
Thanos L, Mylona S, Galani D, Tzavoulis D, Kalioras V, Tanteles S, Pomoni M (2008) Radiofrequency ablation of osseous metastases. Skeletal Radiol 37:189–194
Toyota N, Naito A, Kakizawa H, Hieda M, Hirai N, Tachikake T, Kimura T, Fukuda H, Ito K (2005) Radiofrequency ablation therapy combined with cementoplasty for painful bone metastases: initial experience. Cardiovasc Intervent Radiol 28:578–583
Rossi G, Mavrogenis AF, Rimondi E, Braccaioli L, Calabrò T, Ruggieri P (2011) Selective embolization with N-butyl cyanoacrylate for metastatic bone disease. J Vasc Interv Radiol 22:462–470
De Cristofaro R, Biagini R, Boriani S, Ricci S, Ruggieri P, Rossi G, Fabbri N, Roversi R (1992) Selective arterial embolization in the treatment of aneurysmal bone cyst and angioma of bone. Skeletal Radiol 21:523–527
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Hardes, J. (2012). How to Manage Osteolytic Lesions. In: Bentley, G. (eds) European Instructional Lectures. European Instructional Lectures, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27293-6_5
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DOI: https://doi.org/10.1007/978-3-642-27293-6_5
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