Investigation of Improved Double Quantum Coherence Filter for Localized Detection of Brain γ-Aminobutyric Acid at 1.5T
A single voxel proton point-resolved spectroscopy (PRESS)-localized double quantum filter was introduced at 1.5T clinical scanner for the detection of Brainγ-Aminobutyric Acid (GABA). This method selectively prepares GABA into a double quantum coherence state and suppresses all other resonances at 3.01ppm in each single scan. In phantom experiments, the optimal echo time, the editing efficiency and the degree of suppression of uncoupled resonances were examined after numerical analysis of the editing performance. Excellent GABA signal retention at 3.01ppm was achieved and the spectral editing efficiency was approximately 40%. The suppressed Cr ratio and suppressed NAA ratio were 1118:1 at 3.0ppm and 1815:1 at 2.02ppm respectively.
KeywordsPRESS double quantum filter GABA spectral editing
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