Mitochondrial Dysfunction after Traumatic Brain Injury
Traumatic brain injury (TBI) is the leading cause of death and disability in the world’s population under 45 years of age. About 10% of cases of TBI are severe (Glasgow Coma Scale [GCS] score ≤ 8 points); in this subgroup, the incidence of poor neurological outcome (severe disability, vegetative state or death) still exceeds 55% inmany centers . The endpoints in the early treatment of TBI are adequate and aggressive resuscitation and patient management in the neurointensive care unit is focused on the avoidance and treatment of high intracranial pressure (ICP). To date, no neuroprotective therapy has proven effective in controlled clinical trials involving severe TBI and the International Mission for Prognosis and Analysis of Clinical Trials inTBI (IMPACT) study showed that despite a significant reduction in mortality, neurological sequelae in TBI survivors have not changed significantly in the last 25 years .
KeywordsTraumatic Brain Injury Mitochondrial Dysfunction Traumatic Brain Injury Patient Severe Head Injury Poor Neurological Outcome
Unable to display preview. Download preview PDF.
- 2.Gomez PA, Lobato RD, Gonzalez P, et al (1999) Severe head injury. Hospital 12 de Octubre data base. Description of the data and analysis of the final outcome. Neurocirugía 10: 297–308Google Scholar
- 21.Harzing AW (2007) Publish or Perish. Available at http://www.harzing.com/pop.htm. Accessed Nov 2011Google Scholar
- 26.Poca MA, Sahuquillo J, Mena MP, Vilalta A, Riveiro M (2005) [Recent advances in regional cerebral monitoring in the neurocritical patient: brain tissue oxygen pressure monitoring, cerebral microdialysis and near-infrared spectroscopy.] Neurocirugía (Astur) 16: 385–410Google Scholar
- 38.Szabó C, Zingarelli B, O’Connor M, Salzman AL (1996) DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite. Proc Natl Acad Sci USA 93: 1753–1758PubMedCrossRefGoogle Scholar