Possible Role of NGAL as an Early Renal Biomarker

  • S. Kokkoris
  • S. Nanas
  • P. Andrews
Part of the Annual Update in Intensive Care and Emergency Medicine book series (AUICEM, volume 2012)


The incidence of acute kidney injury (AKI) in critically ill patients is currently increasing [1]. Even though serum creatinine (sCr) is currently used for AKI diagnosis, it is an insensitive and unreliable marker during acute alterations of renal function [2]. The lack of an early biomarker is an obstacle for the development of new preventive strategies and timely interventions against AKI [2]. Recent research for novel biomarkers with early diagnostic and/or prognostic value has revealed several candidates, including neutrophil gelatinase-associated lipocalin (NGAL) [3, 4], cystatin C (CysC) [5, 6], kidney injury molecule 1 (KIM-1) [7], and interleukin 18 (IL-18) [8–11], with NGAL being the most promising so far.


Acute Kidney Injury Acute Kidney Injury Network Rifle Criterion Rifle Category Acute Kidney Injury Diagnosis 
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© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • S. Kokkoris
  • S. Nanas
  • P. Andrews

There are no affiliations available

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