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Cerebral Blood Flow after Cardiac Arrest

  • L. L. A. Bisschops
  • C. W. E. Hoedemaekers
  • J. G. van der Hoeven
Part of the Annual Update in Intensive Care and Emergency Medicine book series (AUICEM, volume 2012)

Abstract

Patients resuscitated from a cardiac arrest have a high (in-hospital) mortality rate between 50–90 %. Although in the past few decades more patients have a return of spontaneous circulation (ROSC), overall prognosis has not substantially improved [1] and only a minority of patients survive with a favorable neurological recovery [2]. In 1972, Negovsky described the ‘post-resuscitation syndrome’, a constellation of pathophysiological processes occurring after ROSC. In 2008, the International Liaison Committee on Resuscitation (ILCOR) proposed a new term: The post-cardiac arrest syndrome [3]. Growing understanding of the post-cardiac arrest syndrome has contributed to the development of new therapeutic strategies. For example, mild therapeutic hypothermia was effective in improving neurological outcome after cardiac arrest in two randomized controlled trials [4,5]. These results were recently confirmed in a retrospective, multicenter observational study showing that the implementation of mild therapeutic hypothermia in Dutch intensive care units (ICUs) was associated with a 20 % relative reduction in hospital mortality [6].

Keywords

Cerebral Blood Flow Cardiac Arrest Mild Therapeutic Hypothermia Cardiac Arrest Patient Cerebrovascular Reactivity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • L. L. A. Bisschops
  • C. W. E. Hoedemaekers
  • J. G. van der Hoeven

There are no affiliations available

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