Cerebral Blood Flow after Cardiac Arrest
Patients resuscitated from a cardiac arrest have a high (in-hospital) mortality rate between 50–90 %. Although in the past few decades more patients have a return of spontaneous circulation (ROSC), overall prognosis has not substantially improved  and only a minority of patients survive with a favorable neurological recovery . In 1972, Negovsky described the ‘post-resuscitation syndrome’, a constellation of pathophysiological processes occurring after ROSC. In 2008, the International Liaison Committee on Resuscitation (ILCOR) proposed a new term: The post-cardiac arrest syndrome . Growing understanding of the post-cardiac arrest syndrome has contributed to the development of new therapeutic strategies. For example, mild therapeutic hypothermia was effective in improving neurological outcome after cardiac arrest in two randomized controlled trials [4,5]. These results were recently confirmed in a retrospective, multicenter observational study showing that the implementation of mild therapeutic hypothermia in Dutch intensive care units (ICUs) was associated with a 20 % relative reduction in hospital mortality .
KeywordsCerebral Blood Flow Cardiac Arrest Mild Therapeutic Hypothermia Cardiac Arrest Patient Cerebrovascular Reactivity
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- 3.Neumar RW, Nolan JP, Adrie C, et al (2008) Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council. Circulation 118: 2452–2483PubMedCrossRefGoogle Scholar