Neurogenic Pulmonary Edema

  • D. L. Davison
  • M. Terek
  • L. S. Chawla
Part of the Annual Update in Intensive Care and Emergency Medicine book series (AUICEM, volume 2012)


Neurogenic pulmonary edema (NPE) is a clinical syndrome characterized by the acute onset of pulmonary edema following a significant central nervous system (CNS) insult. The etiology is thought to be a surge of catecholamines that results in cardiopulmonary dysfunction. A myriad of CNS events, including spinal cord injury, subarachnoid hemorrhage (SAH), traumatic brain injury (TBI), intracranial hemorrhage, status epilepticus, meningitis, and subdural hemorrhage, have been associated with this syndrome [1–5]. Although NPE was identified over 100 years ago, it is still underappreciated in the clinical arena. Its sporadic and relatively unpredictable nature and a lack of etiologic-specific diagnostic markers and treatment modalities may in part be responsible for its poor recognition at the bedside. In this manuscript, we will review the anatomical origin of NPE, outline the various possible pathophysiologic mechanisms responsible for its development, and propose a clinical framework for the classification of NPE.


Traumatic Brain Injury Pulmonary Edema Traumatic Brain Injury Patient Central Nervous System Injury Pulmonary Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • D. L. Davison
  • M. Terek
  • L. S. Chawla

There are no affiliations available

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