Transfusion-related Pulmonary Complications

  • A. D. Goldberg
  • L. Clifford
  • D. J. Kor
Part of the Annual Update in Intensive Care and Emergency Medicine book series (AUICEM, volume 2012)


Physicians have long recognized, though incompletely understood, the respiratory symptoms their patients may manifest after receiving a blood product transfusion [1, 2]. Today, two distinct pulmonary transfusion reactions are recognized as the likely etiology. Although both share a similar clinical phenotype of pulmonary edema and hypoxemic respiratory insufficiency, each have different management schemes and preventative strategies [3–6]. One reaction, called transfusionrelated acute lung injury (TRALI) is a life-threatening complication marked by acute inflammation and injury to the pulmonary parenchyma and vasculature with resultant alveolar flooding. The second, transfusion-associated circulatory overload (TACO) results from the compensatory capacity of the cardiovascular system being overwhelmed by an increase in intravascular volume. This overloaded state manifests as respiratory distress from hydrostatic pulmonary edema.


Pulmonary Edema Acute Lung Injury Prothrombin Complex Concentrate Transfusion Reaction Intravascular Volume Status 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • A. D. Goldberg
  • L. Clifford
  • D. J. Kor

There are no affiliations available

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