Role of the Renin-Angiotensin System in ARDS

  • V. Zambelli
  • A. Grassi
  • G. Bellani
Part of the Annual Update in Intensive Care and Emergency Medicine book series (AUICEM, volume 2012)


The renin-angiotensin system (RAS) is a powerful biological system that plays an important role in regulation of systemic blood pressure through the maintenance of fluid and salt homeostasis. It is a multifactorial system since it includes different components (Fig. 1): The first, renin, was discovered in 1898 [1], whereas the discovery of the last component, angiotensin-converting enzyme 2 (ACE 2), is relatively recent, from 2000 [2, 3]. Three kinds of RAS are known: A) circulating, B) local, and C) intracellular.


Acute Lung Injury Acute Respiratory Distress Syndrome Severe Acute Respiratory Syndrome Alveolar Epithelial Cell Acute Respiratory Distress Syndrome Patient 
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© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • V. Zambelli
  • A. Grassi
  • G. Bellani

There are no affiliations available

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