Sepsis Stewardship Programs: Methods and Results

  • M. Girardis
  • S. Busani
  • A. Pan
Part of the Annual Update in Intensive Care and Emergency Medicine book series (AUICEM, volume 2012)


Hospital mortality in patients with severe sepsis and septic shock is still unacceptably high despite advances in understanding of the physiopathology and the numerous clinical trials on potential therapies. Even with optimal treatment, the mortality rate of patients with septic shock exceeds 40 % and has not varied significantly in the last 5 years [1,2]. Early identification and proper management of patients with sepsis are key factors for reducing the observed mortality and have been the main goal of the Surviving Sepsis Campaign (SSC) by the development of evidence-based guidelines and the recommendation of specific bundles of care [3,4]. Some studies have reported a potential benefit on patient outcome by implementing guidelines and bundle care strategies in clinical practice but wide adoption of these approaches is rare. Moreover, it is still unclear whether the observed benefit is more due to the effect of the recommended treatments or to a general increase in the awareness of the sepsis problem as a result of specific educational and stewardship programs.


Septic Shock Severe Sepsis Septic Shock Patient Absolute Risk Reduction Survive Sepsis Campaign 
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© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • M. Girardis
  • S. Busani
  • A. Pan

There are no affiliations available

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