Hypogammaglobulinemia in Sepsis

  • M. Päsler
  • S. Dietz
  • K. Werdan
Part of the Annual Update in Intensive Care and Emergency Medicine book series (AUICEM, volume 2012)


Immunoglobulin (Ig) preparations are widely used as adjunctive sepsis therapies. The rationale for this treatment concept is the hypothesis that low endogenous serum levels of IgG, IgM or IgA may dispose to severe infection and sepsis, and that substitution with the respective immunoglobulins — either one of the many intravenous IgG preparations or the intravenous IgGMA preparation, Pentaglobin®, might improve prognosis. The following article offers an overview on adjunctive immunoglobulin therapy in adult patients with severe sepsis. For prophylaxis of sepsis in adults see [1], for prophylaxis and therapy of sepsis in neonates and infants see [1, 2].


Septic Shock Severe Sepsis Critical Illness Polyneuropathy Streptococcal Toxic Shock Syndrome Immunoglobulin Preparation 
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© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • M. Päsler
  • S. Dietz
  • K. Werdan

There are no affiliations available

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