The Relation Between the Gene Network and the Physical Structure of Chromosomes

  • Dieter W. Heermann
  • Manfred Bohn
  • Philipp M. Diesinger
Conference paper


Human cells contain 46 chromosomes with a total length of about 5 cm beads-ona- string type of nucleosomal fibre, called chromatin. Packaging this into a nucleus of typically 5–20 μm diameter requires extensive compatification. This packaging cannot be random, as considerable evidence has been gathered that chromatin folding is closely related to local genome function. However, the different levels of compactification are ill understood and not easily accessible by experiments.


Interphase Nucleus Polymer Model Nucleosome Occupancy Linker Histone Depletion Effect 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Dieter W. Heermann
    • 1
  • Manfred Bohn
    • 1
  • Philipp M. Diesinger
    • 1
  1. 1.Institute for Theoretical PhysicsUniversity of HeidelbergHeidelbergGermany

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