Light Syringes Based on the Laser Induced Shock Wave

  • T. Han
  • J. Hah
  • S. Kim
  • Jack J. Yoh
Conference paper


Drug Needle injectors have been the common means by which vaccines and protein therapeutics are transdermally delivered. However, the use of needle injectors have elicited painful reactions, and have also caused infection due to repeated use of needles particularly in under-developed countries [1]. Because of these disadvantages, researchers have endeavored to developing alternative methods for drug delivery. New methods incorporating liquid jet injections have been developed [2]; however, liquid jet has not succeeded in replacing needle based injectors yet. Despite the fact that jet injection can alleviate patients aversion to needles, it has not gained much popularity for the following reasons: i) it is still reported to be painful, ii) it is not stabilized in control, and iii) the risk of cross-contamination due to back splash is still prevalent [3, 4]. Therefore, in order to release the stronghold that needle injection has on the drug delivery domain, methods such as jet injection must make a major breakthrough.


Shock Wave Nozzle Exit Elastic Membrane Secondary Shock Wave Laser Induce Bubble 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Nir, Y., Paz, A., Potasman, I.: Fear of injections in young adults: prevalence and associations. Am. J. Trop. Med. Hyg. 68(3), 341–344 (2003)Google Scholar
  2. 2.
    Mitragotri, S.: Current status and future potential of transdermal drug delivery. Nat. Rev. Drug Discov. 3, 115–124 (2004)CrossRefGoogle Scholar
  3. 3.
    Theintz, G.E., Sizonenko, P.C.: Risks of jet injection of insulin in children. Eur. J. Pediatr. 150(8), 554–556 (1991)CrossRefGoogle Scholar
  4. 4.
    Hoffman, P.N., Abuknesha, R.A., Andrews, N.J., Samuel, D., Lloyd, J.S.: A model to assess the infection potential of jet injectors used in mass immunization. Vaccine 19(28), 4020–4027 (2001)CrossRefGoogle Scholar
  5. 5.
    Han, T., Gojani, A.B., Yoh, J.J.: Biolistic injection of micro particles with high power Nd:YAG laser. Appl. Opt. 49(16), 3035–3041 (2010)CrossRefGoogle Scholar
  6. 6.
    Han, T., Yoh, J.J.: A laser based reusable microjet injector for transdermal drug delivery. J. Applied Physics 107, 103–110 (2010)Google Scholar
  7. 7.
    Stachowiak, J.C., Li, T.H., Arora, A., Mitragotri, S., Fletcher, D.A.: Dynamic control of needle-free jet injection. J. of Cont. Release 135(2), 104–112 (2009)CrossRefGoogle Scholar
  8. 8.
    Shangguan, H., Casperson, L.W., Shearin, A., Gregory, K.W., Prahl, S.A.: Drug delivery with microsecond laser pulses into gelatin. Appl. Opt. 35(19), 3347–3357 (1996)CrossRefGoogle Scholar
  9. 9.
    Rosenschein, U., Frimerman, A., Laniado, S., Miller, H.I.: Study of the mechanism of ultrasound angioplasty from human thrombi and bovine aorta. Am. J. Cardiol. 74(12), 1263–1266 (1994)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • T. Han
    • 1
  • J. Hah
    • 1
  • S. Kim
    • 1
  • Jack J. Yoh
    • 1
  1. 1.School of Mechanical and Aerospace EngineeringSeoul National UniversitySeoulKorea

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