Advertisement

Reserpine Caused Gastrointestinal Damages and Hormonal Changes in Rats

  • Kaijun Guo
  • Fei Cheng
  • Xiaorui Wang
  • Xiaoping Song
  • Xiaoyu Zhu
  • Jingyi Gan
  • Fenghua Liu
  • Jianqin Xu
Conference paper
Part of the Advances in Intelligent and Soft Computing book series (AINSC, volume 115)

Abstract

The aim of the present study is to investigate the changes of gastrointestinal (GI) hormones in reserpine-treated rat. Reserpine (0.5 mg/kg body weight) was injected once per day for continuous 14 days. The histological changes of GI were observed and GI hormones variation was measured. The results showed that comparing with the control group, the reserpine-treated rats had obvious damages. In the GI damaged duodenum mRNA and protein content of gastrin (GAS), cholecystokinin (CCK), vasoactive intestinal polypeptide (VIP) were significantly decreased and somatostatin (SS) protein content were significantly increased comparing the control group. In the gastric antrum of reserpine-treated rats, mRNA and protein content of GAS increased significantly while those of CCK were significantly decreased comparing the control group. These results suggest that the GI hormones changes were associated with gastro and small intestine damage in reserpine-treated rats.

Keywords

Reserpine-treated rat GI damage GI hormone 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Little, T.J., Feltrin, K.L., Horowitz, M., Smout, A.J., Rades, T., Meyer, J.H., et al.: Dose-related effects of lauric acid on antropyloroduodenal motility, gastrointestinal hormone release, appetite, and energy intake in healthy men. Am. J. Physiol. Regul. Integr. Comp. Physiol. 289(4), R1090–R1098 (2005)Google Scholar
  2. 2.
    Thomas, R.P., Hellmich, M.R., Townsend Jr., C.M., Evers, B.M.: Role of gastrointestinal hormones in the proliferation of normal and neoplastic tissues. Endocr. Rev. 24(5), 571–599 (2003)CrossRefGoogle Scholar
  3. 3.
    Seva, C., Dickinson, C.J., Yamada, T.: Growth-promoting effects of glycine-extended progastrin. Science 265(5170), 410–412 (1994)CrossRefGoogle Scholar
  4. 4.
    Ancha, H., Ojeas, H., Tedesco, D., Ward, A., Harty, R.F.: Somatostatin-induced gastric protection against ethanol: involvement of nitric oxide and effects on gastric mucosal blood flow. Regul. Pept. 110(2), 107–113 (2003)CrossRefGoogle Scholar
  5. 5.
    Forster, E.R., Green, T., Elliot, M., Bremner, A., Dockray, G.J.: Gastric emptying in rats: role of afferent neurons and cholecystokinin. Am. J. Physiol. 258(4 Pt 1), G552–G556 (1990)Google Scholar
  6. 6.
    Cantarella, G., Martinez, G., Di Benedetto, G., Loreto, C., Musumeci, G., Prato, A., et al.: Protective effects of amylin on reserpine-induced gastric damage in the rat. Pharmacol. Res. 56(1), 27–34 (2007)CrossRefGoogle Scholar
  7. 7.
    Singh, I.: On argyrophile and argentaffin reactions in individual granules of enterochromaffin cellas of the Human gastro-intestinal tract. J. Anat. 98, 497–500 (1964)Google Scholar
  8. 8.
    Tanemura, A., Yano, T., Tamaki, H., Sanda, T., Ohashi, N., Ishihara, A., et al.: Ectopic pancreas in the minor duodenal papilla presenting as upper-GI bleeding. Gastrointest Endosc. 62(2), 324–326 (2005)CrossRefGoogle Scholar
  9. 9.
    Anlauf, M., Perren, A., Henopp, T., Rudolf, T., Garbrecht, N., Schmitt, A., et al.: Allelic deletion of the MEN1 gene in duodenal gastrin and somatostatin cell neoplasms and their precursor lesions. Gut. 56(5), 637–644 (2007)CrossRefGoogle Scholar
  10. 10.
    Yao, Y.L., Xu, B., Zhang, W.D., Song, Y.G.: Gastrin, somatostatin, and experimental disturbance of the gastrointestinal tract in rats. World J. Gastroenterol. 7(3), 399–402 (2001)Google Scholar
  11. 11.
    Karmeli, F., Eliakim, R., Okon, E., Rachmlewitz, D.: Role of vasoactive intestinal peptide (VIP) in pathogenesis of ethanol-induced gastric mucosal damage in rats. Dig. Dis. Sci. 38(7), 1210–1219 (1993)CrossRefGoogle Scholar
  12. 12.
    Giralt, M., Vergara, P.: Inhibition by CCK of ascending contraction elicited by mucosal stimulation in the duodenum of the rat. Neurogastroenterol. Motil. 12(2), 173–180 (2000)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Berlin Heidelberg 2012

Authors and Affiliations

  • Kaijun Guo
    • 1
  • Fei Cheng
    • 2
    • 3
  • Xiaorui Wang
    • 2
  • Xiaoping Song
    • 2
  • Xiaoyu Zhu
    • 3
  • Jingyi Gan
    • 3
  • Fenghua Liu
    • 1
  • Jianqin Xu
    • 3
  1. 1.College of Animal Science and TechnologyBeijing University of AgricultureBeijingP.R China
  2. 2.College of Veterinary MedicineNorthwest A&F UniversityYanglingP.R China
  3. 3.College of Veterinary MedicineChina Agricultural UniversityBeijingP.R. China

Personalised recommendations