The Bird Genome and the Molecular Determination of Wings, Legs and Beaks

  • A. Lima-de-Faria


The DNA sequencing of the human and red jungle fowl genomes revealed that there are so many similarities between the two species that the genes cannot only be recognized as being the same, but are supposed to function similarly.

Molecular biology has advanced so rapidly in the last decade that what was considered impossible became possible. Genetic manipulation of specific genes has allowed to produce birds with extra normal wings and extra normal legs.

Moreover, the great variation in beak morphology, which has been the source of great interest to students of evolution, has turned out to be directed by simple proteins. Beak evolution has been recreated in the laboratory by modifying the bills of ducks and finches.


Zebra Finch Chicken Genome Galapagos Island Chicken Gene Tree Finch 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Abzhanov A et al (2004) Bmp4 and morphological variation of beaks in Darwin’s finches. Science 305:1462–1464PubMedCrossRefGoogle Scholar
  2. Abzhanov A et al (2006) The calmodulin pathway and evolution of elongated beak morphology in Darwin’s finches. Nature 442:563–567PubMedCrossRefGoogle Scholar
  3. Axelsson E et al (2005) Comparison of the chicken and turkey genomes reveals a higher rate of nucleotide divergence on microchromosomes than macrochromosomes. Genome Res 15:120–125PubMedCrossRefGoogle Scholar
  4. Balakrishnan CN et al (2010) The Zebra Finch genome and avian genomics in the wild. Roy Austral Ornitholog Union Emu 110:233–241CrossRefGoogle Scholar
  5. Baltimore D (2001) Our genome unveiled. Nature 409:814–816PubMedCrossRefGoogle Scholar
  6. Beazley M (1974) The world atlas of birds. Mitchell Beazley Publishers Limited, LondonGoogle Scholar
  7. Bork P, Copley R (2001) Filling in the gaps. Nature 409:818–820PubMedCrossRefGoogle Scholar
  8. Brown TA (1999) Genomes. Bios Scientific Publishers, OxfordGoogle Scholar
  9. Christiano AM et al (1994) Structural organization of the human type VII collagen gene (COL7A1), composed of more exons than any previously characterized gene. Genomics 21:169–179PubMedCrossRefGoogle Scholar
  10. Cohn MJ et al (1997) Hox9 genes and vertebrate limb specification. Nature 387:97–101PubMedCrossRefGoogle Scholar
  11. Fritsch EF et al (1980) Molecular cloning and characterization of the human α-like globin gene cluster. Cell 19:959–972PubMedCrossRefGoogle Scholar
  12. Grant PR, Grant BR (2002) Adaptive radiation of Darwin’s finches. Am Sci 90:130–139CrossRefGoogle Scholar
  13. Grant PR, Grant BR (2008) How and why species multiply: the radiation of Darwin’s finches. Princeton University Press, PrincetonGoogle Scholar
  14. Hellsten U et al (2010) The genome of the western clawed frog Xenopus tropicalis. Science 328:633–636PubMedCrossRefGoogle Scholar
  15. International Chicken Genome Sequencing Consortium (incl. L. Andersson and H. Ellegren) (2004) Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution. Nature 432:695–715CrossRefGoogle Scholar
  16. Isaac A et al (1998) Tbx genes and limb identity in chick embryo development. Development 125:1867–1875PubMedGoogle Scholar
  17. Lima-de-Faria A (2003) One hundred years of chromosome research and what remains to be learned. Kluwer Academic Publishers, DordrechtGoogle Scholar
  18. Lima-de-Faria A (2008a) Praise of chromosome ”folly”. Confessions of an untamed molecular structure. World Scientific, SingaporeCrossRefGoogle Scholar
  19. Logan M et al (1998) Differential regulation of T-box and homeobox transcription factors suggests roles in controlling chick limb-type identity. Development 125:2825–2835PubMedGoogle Scholar
  20. Ohuchi H et al (1998) Correlation of wing-leg identity in ectopic FGF-induced chimeric limbs with the differential expression of chick Tbx5 and Tbx4. Development 125:51–60PubMedGoogle Scholar
  21. Patel NH (2006) How to build a longer beak. Nature 442:515–516PubMedCrossRefGoogle Scholar
  22. Pennisi E (2003) Gene counters struggle to get the right answer. Science 301:1040–1041PubMedCrossRefGoogle Scholar
  23. Pennisi E (2004) Bonemaking protein shapes beaks of Darwin’s finches. Science 305:1383PubMedCrossRefGoogle Scholar
  24. Perrins C (ed) (2003) The world encyclopedia of birds. Oxford University Press, OxfordGoogle Scholar
  25. Pough FH et al (2005) Vertebrate life. Pearson Prentice Hall, Upper Saddle River, NJGoogle Scholar
  26. Rodriguez-Esteban C et al (1999) The T-box genes Tbx4 and Tbx5 regulate limb outgrowth and identity. Nature 398:814–818PubMedCrossRefGoogle Scholar
  27. Segal E et al (2006) A genomic code for nucleosome positioning. Nature 442:772–778PubMedCrossRefGoogle Scholar
  28. Strachan T, Read AP (1996) Human molecular genetics. BIOS Scientific Publishers, OxfordGoogle Scholar
  29. Warren WC et al (2010) The genome of a songbird. Nature 464:757–763PubMedCrossRefGoogle Scholar
  30. Wu P et al (2004) Molecular shaping of the beak. Science 305:1465–1466PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Cell and Organism BiologyLund UniversityLundSweden
  2. 2.LundSweden

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