Thermoresponsive Spin-Labeled Hydrogels as Separable DNP Polarizing Agents

  • Matthias J. N. Junk
Part of the Springer Theses book series (Springer Theses)


Dynamic nuclear polarization (DNP) is a commonly applied NMR hyperpolarization technique, which is based on the polarization transfer from electron spins to nuclear spins. While DNP allows a significant enhancement of NMR signals by several orders of magnitude, major drawbacks of the method include enhanced nuclear relaxation times due to the presence of unpaired electrons and the toxicity of radicals, which is the limiting factor for in vivo applications in magnetic resonance imaging. Thus, an efficient separation of the polarization agent is a key requirement for possible applications in medicine. In this chapter, the application of spin-labeled thermoresponsive hydrogels as polarizing agents for dynamic nuclear polarization is explored.


Dynamic Nuclear Polarization Nuclear Magnetic Resonance Signal Chemically Induce Dynamic Nuclear Polarization Leakage Factor Dynamic Nuclear Polarization Enhancement 
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  1. 1.
    Bargon J, Fischer H, Johnsen U (1967) Z Naturforsch A 22:1551–1555Google Scholar
  2. 2.
    Bargon J, Fischer H (1967) Z Naturforsch A 22:1556–1562Google Scholar
  3. 3.
    Hore PJ, Broadhurst RW (1993) Prog Nucl Magn Reson Spectrosc 25:345–402CrossRefGoogle Scholar
  4. 4.
    Matysik J, Diller A, Roy E, Alia A (2009) Photosynth Res 102:427–435CrossRefGoogle Scholar
  5. 5.
    Bowers CR, Weitekamp DP (1986) Phys Rev Lett 57:2645–2648CrossRefGoogle Scholar
  6. 6.
    Bowers CR, Weitekamp DP (1987) J Am Chem Soc 109:5541–5542CrossRefGoogle Scholar
  7. 7.
    Eisenschmid TC, Kirss RU, Deutsch PP, Hommeltoft SI, Eisenberg R, Bargon J, Lawler RG, Balch AL (1987) J Am Chem Soc 109:8089–8091CrossRefGoogle Scholar
  8. 8.
    Pravica MG, Weitekamp DP (1988) Chem Phys Lett 145:255–258CrossRefGoogle Scholar
  9. 9.
    Goodson BM (2002) J Magn Reson 155:157–216CrossRefGoogle Scholar
  10. 10.
    Overhauser AW (1953) Phys Rev 92:411–415CrossRefGoogle Scholar
  11. 11.
    Carver TR, Slichter CP (1953) Phys Rev 92:212–213CrossRefGoogle Scholar
  12. 12.
    Carver TR, Slichter CP (1956) Phys Rev 102:975–980CrossRefGoogle Scholar
  13. 13.
    Becerra LR, Gerfen GJ, Temkin RJ, Singel DJ, Griffin RG (1993) Phys Rev Lett 71:3561–3564CrossRefGoogle Scholar
  14. 14.
    Bowen S, Hilty C (2008) Angew Chem Int Ed 47:5235–5237CrossRefGoogle Scholar
  15. 15.
    Bajaj VS, Mak-Jurkauskas ML, Belenky M, Herzfeld J, Griffin RG (2009) Proc Nat Acad Sci USA 106:9244–9249CrossRefGoogle Scholar
  16. 16.
    Day SE, Kettunen MI, Gallagher FA, Hu DE, Lerche M, Wolber J, Golman K, Ardenkjaer-Larsen JH, Brindle KM (2007) Nat Med 13:1521CrossRefGoogle Scholar
  17. 17.
    Golman K, in’t Zandt R, Lerche M, Pehrson R, Ardenkjaer-Larsen JH (2006) Cancer Res 66:10855–10860CrossRefGoogle Scholar
  18. 18.
    Gallagher FA, Kettunen MI, Day SE, Hu DE, Ardenkjaer-Larsen JH, in’t Zandt R, Jensen PR, Karlsson M, Golman K, Lerche MH, Brindle KM (2008) Nature 453:940–943CrossRefGoogle Scholar
  19. 19.
    Prisner T, Köckenberger W (2008) Appl Magn Reson 34:213–218CrossRefGoogle Scholar
  20. 20.
    Sezer D, Gafurov M, Prandolini MJ, Denysenkov VP, Prisner TF (2009) Phys Chem Chem Phys 11:6638–6653CrossRefGoogle Scholar
  21. 21.
    McCarney ER, Armstrong BD, Lingwood MD, Han S (2007) Proc Nat Acad Sci USA 104:1754–1759CrossRefGoogle Scholar
  22. 22.
    McCarney ER, Armstrong BD, Kausik R, Han S (2008) Langmuir 24:10062–10072CrossRefGoogle Scholar
  23. 23.
    Armstrong BD, Lingwood MD, McCarney ER, Brown ER, Blümler P, Han S (2008) J Magn Reson 191:273–281CrossRefGoogle Scholar
  24. 24.
    Münnemann K, Bauer C, Schmiedeskamp J, Spiess HW, Schreiber WG, Hinderberger D (2008) Appl Magn Reson 34:321–330CrossRefGoogle Scholar
  25. 25.
    Song C, Hu K-N, Joo C-G, Swager TM, Griffin RG (2006) J Am Chem Soc 128:11385–11390CrossRefGoogle Scholar
  26. 26.
    Maly T, Debelouchina GT, Bajaj VS, Hu K-N, Joo C-G, Mak-Jurkauskas ML, Sirigiri JR, van der Wel PCA, Herzfeld J, Temkin RJ, Griffin RG (2008) J Chem Phys 128:052211CrossRefGoogle Scholar
  27. 27.
    Höfer P, Parigi G, Luchinat C, Carl P, Guthausen G, Reese M, Carlomagno T, Griesinger C, Bennati M (2008) J Am Chem Soc 130:3254–3255CrossRefGoogle Scholar
  28. 28.
    Ardenkjaer-Larsen JH, Fridlund B, Gram A, Hansson G, Hansson L, Lerche MH, Servin R, Thaning M, Golman K (2003) Proc Nat Acad Sci USA 100:10158–10163CrossRefGoogle Scholar
  29. 29.
    Comment A, Rentsch J, Kurdzesau F, Jannin S, Uffmann K, van Heeswijk RB, Hautle P, Konter JA, van den Brandt B, van der Klink JJ (2008) J Magn Reson 194:152–155CrossRefGoogle Scholar
  30. 30.
    Gitti R, Wild C, Tsiao C, Zimmer K, Glass TE, Dorn HC (1988) J Am Chem Soc 110:2294–2296CrossRefGoogle Scholar
  31. 31.
    McCarney ER, Han S (2008) J Magn Reson 190:307–315CrossRefGoogle Scholar
  32. 32.
    Thaning M, Servin R (GE Healthcare, Inc.) Method of dynamic nuclear polarisation DNP, USPTO patent application 20080260649, applied on 12-1-2006, published on 10-23-2008Google Scholar
  33. 33.
    Hirotsu S, Hirokawa Y, Tanaka T (1987) J Chem Phys 87:1392–1395CrossRefGoogle Scholar
  34. 34.
    Schild HG (1992) Prog Polym Sci 17:163–249CrossRefGoogle Scholar
  35. 35.
    Hausser KH, Stehlik D (1968) Adv Magn Reson9 3:79–139Google Scholar
  36. 36.
    Nicholson I, Lurie DJ, Robb FJL (1994) J Magn Reson B 104:250–255Google Scholar
  37. 37.
    Benial AMF, Ichikawa K, Murugesan R, Yamada K, Utsumi H (2006) J Magn Reson 182:273–282CrossRefGoogle Scholar
  38. 38.
    Bates RD, Drozdoski WS (1977) J Chem Phys 67:4038–4044CrossRefGoogle Scholar
  39. 39.
    Robinson BH, Haas DA, Mailer C (1994) Science 263:490–493CrossRefGoogle Scholar
  40. 40.
    Armstrong BD, Han S (2007) J Chem Phys 127:104508CrossRefGoogle Scholar
  41. 41.
    Beines PW, Klosterkamp I, Menges B, Jonas U, Knoll W (2007) Langmuir 23:2231–2238CrossRefGoogle Scholar
  42. 42.
    Gianneli M, Beines PW, Roskamp RF, Koynov K, Fytas G, Knoll W (2007) J Phys Chem C 111:13205–13211CrossRefGoogle Scholar
  43. 43.
    Junk MJN, Jonas U, Hinderberger D (2008) Small 4:1485–1493CrossRefGoogle Scholar
  44. 44.
    Cao Y, Zhu XX, Luo J, Liu H (2007) Macromolecules 40:6481–6488CrossRefGoogle Scholar
  45. 45.
    Cao Y, Zhao N, Wu K, Zhu XX (2009) Langmuir 25:1699–1704CrossRefGoogle Scholar
  46. 46.
    Atherton NM (1993) Principles of electron spin resonance. Ellis Horwood, New YorkGoogle Scholar
  47. 47.
    Han S, McCarney ER, Armstrong BD (2008) Appl Magn Reson 34:439–451CrossRefGoogle Scholar
  48. 48.
    Wind RA, Duijvestijn MJ, van der Lugt C, Manenschijn A, Vriend J (1985) Prog Nucl Magn Reson Spectrosc 17:33–67CrossRefGoogle Scholar
  49. 49.
    Abragam A, Goldman M (1978) Rep Prog Phys 41:395–467CrossRefGoogle Scholar
  50. 50.
    Hu K-N, Yu H-h, Swager TM, Griffin RG (2004) J Am Chem Soc 126:10844–10845CrossRefGoogle Scholar
  51. 51.
    Hu K-N, Song C, Yu H-h, Swager TM, Griffin RG (2008) J Chem Phys 128:052302CrossRefGoogle Scholar
  52. 52.
    Shea KJ, Stoddard GJ, Shavelle DM, Wakui F, Choate RM (1990) Macromolecules 23:4497–4507CrossRefGoogle Scholar
  53. 53.
    Toomey R, Freidank D, Rühe J (2004) Macromolecules 37:882–887CrossRefGoogle Scholar
  54. 54.
    Dollmann BC, Junk MJN, Drechsler M, Spiess HW, Hinderberger D, Münnemann K (2010) Phys Chem Chem Phys 12:5879–5882CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Max Planck Institute for Polymer ResearchMainzGermany

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