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Maternal Obesity and Pregnancy pp 271–281Cite as

Obesity in Pregnancy: Data from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study

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Abstract

The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study has provided an opportunity to assess the relative associations of maternal glycemia measured at an oral glucose tolerance test (mean 28 weeks gestation) and maternal body mass index with a range of adverse pregnancy outcomes, without many of the potential confounding factors seen in previous studies. The HAPO study confirmed independently significant associations between maternal BMI and birthweight >90th centile, frequency of primary cesarean section, neonatal hypoglycemia, neonatal hyperinsulinemia, preeclampsia, and neonatal adiposity. The combination of maternal obesity and gestational diabetes was associated with higher frequencies of adverse outcomes than either variable in isolation.

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Acknowledgements

The authors acknowledge the HAPO Study Steering Committee for their assistance in the final reviews of this document.

Author information

Authors and Affiliations

  1. University of Queensland and Mater Medical Research Institute, South Brisbane, Queensland, Australia

    Harold David McIntyre M.D.

  2. Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Lynn P. Lowe Ph.D.

  3. Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, USA

    Alan R. Dyer Ph.D.

  4. Division of Endocrinology, Metabolism & Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Boyd E. Metzger M.D.

Authors
  1. Harold David McIntyre M.D.
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  2. Lynn P. Lowe Ph.D.
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  3. Alan R. Dyer Ph.D.
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  4. Boyd E. Metzger M.D.
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Corresponding author

Correspondence to Harold David McIntyre M.D. .

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Editors and Affiliations

  1. , Department of Obstetrics and Gynecology, Aarhus University Hospital, Skejby, Brendstrupgaardsvej 1, Aarhus N, 8200, Denmark

    Per Glud Ovesen

  2. , Department of Endocrinology, Odense University Hospital, Kløvervænget 6, Odense C, 5000, Denmark

    Dorte Møller Jensen

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© 2012 Springer-Verlag Berlin Heidelberg

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McIntyre, H.D., Lowe, L.P., Dyer, A.R., Metzger, B.E. (2012). Obesity in Pregnancy: Data from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study. In: Ovesen, P., Møller Jensen, D. (eds) Maternal Obesity and Pregnancy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25023-1_17

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  • DOI: https://doi.org/10.1007/978-3-642-25023-1_17

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-25022-4

  • Online ISBN: 978-3-642-25023-1

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